Cytoskeleton of the Nervous System, Softcover reprint of the original 1st ed. 2011 Advances in Neurobiology Series, Vol. 3

This monograph begins with a general description of the cytoskeleton in axonal development and pathology and then moves to more detailed descriptions of particular components, including microtubules and associated proteins, neurofilaments and interacting proteins, actin and its binding proteins, and glial fibrillary acidic protein. The later chapters focus on the functional significance of the neuronal cytoskeleton in axonal transport and its regulation in health and disease states. The Cytoskeleton of the Nervous System will encourage further development of unifying principles and stimulate new conceptual and technical approaches toward a better understanding of cytoskeleton functions in health and disease.

Central Axonal Development and Pathology in Early Life.- Microtubules in the nervous system.- Tau phosphorylation.- Tau Pathology.- Tauopathy and brain aging.- Microtubule-associated protein 4.- Structure of Neural Intermediate Filaments.- Alpha-internexin: the Fourth Subunit of Neurofilaments in the Mature CNS.- Peripherin Pathology.- Neurofilament cross-bridge: a structure associated specifically with the neurofilament among the intermediate filament family.- Neurofilament Transport.- Knockout models of neurofilament proteins.- Neurofilaments and Radial Growth: Deconstruction of a hypothesis through the construction of gene targeted mice.- Deregulation of Cytoskeletal Protein Phosphorylation and Neurodegeneration.- Neurofilaments in Aged Animals.- Neurofilament changes in Multiple Sclerosis.- Intermediate filament interactions in neurons.- Tropomyosins in Neuronal Morphogenesis and Development.- The Driving Machinery for Growth Cone Navigation.- Glial Fibrillary Acidic Protein: The intermediate filament protein of astrocytes.- Axonal Transport Mechanisms in Cytoskeleton Formation and Regulation.- Axonal transport and motor neuron disease.- In vivo imaging of axonal transport in aging and Alzheimer's disease.- Regulation of Cytoskeletal Composition in Neurons: Transcriptional and Post-transcriptional Control in Development, Regeneration, and Disease.- Crosstalks between myelinating cells and the axonal cytoskeleton.- Topographic regulation of neuronal intermediate filament proteins by phosphorylation: In health and disease.- Cytoskeleton, axonal transport, and the mechanisms of axonal neuropathy.- Effects of Insulin on Tau and Neurofilament.- Ethanol effects on the cytoskeleton of nerve tissue cells

Ralph A. Nixon is the Director of Silberstein Institute and Center of Excellence on Brain Aging; a Professor of Psychiatry and Cell Biology at NYU Langone Medical Center; the Director of Research and The Center for Dementia Research at Nathan S. Kline Institute for Psychiatric Research. Aidong (David) Yuan is the Research Project Manager at the Center for Dementia Research, Nathan S. Kline Institute; a Research Assistant Professor of Psychiatry at New York University Langone Medical Center and New York University School of Medicine.

Describes cytoskeleton in axonal development and pathology, microtubules and associated proteins, neurofilaments and interacting proteins, actin and its binding proteins, and glial fibrillary acidic protein Focuses on functional significance of neuronal cytoskeleton in axonal transport Encourages further development of unifying principles, stimulates new conceptual and technical approaches toward a better understanding of cytoskeleton functions in health and disease Includes supplementary material: sn.pub/extras