Cushing's Syndrome, 2011 Pathophysiology, Diagnosis and Treatment Contemporary Endocrinology Series

Cushing?s syndrome is a relatively rare clinical disorder that is associated with many co-morbidities such as systemic hypertension, diabetes, osteoporosis, impaired immune function and growth impairment in children, all of which severely reduce quality of life and life expectancy. Cushing?s Syndrome: Pathophysiology, Diagnosis and Treatment reviews the difficulties in distinguishing Cushing?s syndrome from these and other common conditions, such as central obesity, menstrual irregularity and depression. It also provides state-of-the-art information on various strategies to establish the diagnosis of Cushing?s syndrome and the differential diagnosis among its diverse etiologies, as well as therapeutic approaches. Additionally, a range of conditions that represent challenges for the diagnosis and treatment--such as renal failure, pediatric age, cyclic hypercortisolism, and pregnancy--are covered in detail. A valuable resource not only for endocrinologists but also internal medicine physicians, gynecologists, pediatricians, , pituitary surgeons and urologists, Cushing?s Syndrome: Pathophysiology, Diagnosis and Treatment provides insights by experts that will help all physicians dealing with Cushing?s syndrome to expand their knowledge about the condition and provide targeted, comprehensive care.

Physiology and Pathophysiology of the HPA axis.- Etiologies of Cushing´s syndrome.- Pathogenesis of corticotropic tumors.- Pathogenesis of adrenocortical tumors.- Clinical features of Cushing´s syndrome.- Laboratorial diagnosis of Cushing´s Syndrome: Differential diagnosis with pseudo-Cushing´s conditions as obesity, alcoholism and depression.- Laboratorial diagnosis of Cushing´s syndrome: Differential diagnosis among the different causes of ACTH-dependent and ACTH-independent Cushing´s syndrome.- Imaging for the differential diagnosis of Cushing´s syndrome: MRI, CT and isotopic scanning.- Inferior petrosal sampling for the differential diagnosis of ACTH dependent Cushing´s syndrome.- ACTH-dependent Cushing syndrome: Treatment of Cushing´s disease.- Treatment of Cushings Syndrome: Surgical Treatment.- Adrenal-Directed Treatment Options for Cushing’s Disease.- Radiation Therapy and Stereotactic Radiosurgery for Cushing’s Disease.- Medical Management of Cushing’s syndrome.- ACTH-dependent Cushing syndrome: Clinical and diagnostic aspects, and treatment approaches for ectopic Cushing´s syndrome.- Revisiting the Nelson’s syndrome: Corticotroph Tumor Progression after bilateral adrenalectomy in Cushing’s disease.- ACTH-independent Cushing´s syndrome: Adrenocortical tumors.- ACTH-independent Cushing´s syndrome: Bilateral macronodular hyperplasia.- ACTH-independent Cushing´s syndrome: primary pigmented nodular adrenal disease in the context of Carney´s complex.- Glucocorticoid Resistance.- Post-operative replacement and assessment of HPA axis recovery in Cushing’s syndrome.- Special aspects of Cushing´s syndrome: Pregnancy.- Special aspects of Cushing´s syndrome: Childhood.- Special aspects of Cushing´s syndrome: Cyclic Cushing´s syndrome.

Provides up to date information on various strategies to establish the diagnosis of Cushing’s syndrome Approaches to the differential diagnosis and specific treatments for each condition are provided Chapters discuss controversies in diagnosis and differential diagnosis provide a nuanced perspective of these areas Includes supplementary material: sn.pub/extras