Mechanisms in B-Cell Neoplasia 1994, Softcover reprint of the original 1st ed. 1995 Current Topics in Microbiology and Immunology Series, Vol. 194

Contains the results of a workshop on intriguing new developments in human B-cell tumour research, covering B-cell biology and the clinical problems posed by multiple myelomas, follicular lymphoma, mantle cell lymphoma and B-CLL.

The “Myeloma” Clone.- Detection of Peripheral Blood Myeloma Cells by Three-Color Flow Cytometry.- Detection of B-Cells Clonally Related to the Tumor Population in Multiple Myeloma and MGUS.- The Blood B-Cells and Bone Marrow Plasma Cells in Patients with Multiple Myeloma Share Identical IgH Rearrangements.- Multiple Myeloma Clones are Derived from a Cell Late in B Lymphoid Development.- The Myeloma/Plasmacytoma Phenotype.- Multiple Myeloma — Recent Developments in Molecular and Cellular Biology.- Potential Role of CD28-B7 Interactions in the Growth of Myeloma Plasma Cells.- B-1 (CD5+) B-Cells as a Marker of Immune Dysregulation in Multiple Myeloma.- Genes Expressed Selectively in Murine and Human Plasma Cell Neoplasms.- Molecular and Biological Role of CD40 in Multiple Myeloma.- The Proliferation-Associated Cytosolic Protein Lap 18 (stathmin) is Expressed at Atypically Low Levels in BALB/c Plasmacytom Cells.- Plasmacytoma Induction in Mice.- Induction of Plasmacytomas in Genetically Susceptible Mice with Silicone Gels.- Strain-Related Cellular Mechanisms as a Determinant for Susceptibility and Resistance to PC Induction.- Human and Mouse B-Cell Lymphomas.- Alterations of the BCL-6 Gene in Diffuse Large-Cell Lymphoma.- Classification of Mouse Lymphomas.- The Natural History of a Lymphoproliferative Disorder in Aged NZB Mice.- EBV Infection of B-CLL Cells in Vitro Potentiates Their Allostimulatory Capacity if Accompanied by Acquisition of the Activated Phenotype.- A New Form of Epstein-Barr Virus Latency in vivo.- Pharmacologic Activation of Expression of Immunodominant Viral Antigens: A New Strategy for the Treatment of Epstein-Barr-Virus-Associated Malignancies.- Rapid Identification of Novel Human Lymphoid-Restricted Genes by Automated DNA Sequencing ofSubtracted cDNA Libraries.- Tumorigenesis in Mice with an SV40T Antigen Transgene Driven by the Immunoglobulin ?1 Heavy Chain Germline Promoter.- Circulating B-Cells in Follicular Non-Hodgkin’s Lymphoma Show Variant Expression of L-Selectin Epitopes.- Light Chain Loss and Reexpression Leads to Idiotype Switch. Surrogate Light Chains are Probably Responsible for this Process.- Growth Regulation: IL-6.- Regulation of Terminal differentiation of Human B-Cells by IL-6.- Sequence, Expression and Function of an mRNA Encoding a Soluble Form of the Human lnterleukin-6 Receptor (sIL-6R).- The Late B-Cell.- CD5 Transgenic Mice.- Activation of B-Cells by sIgM Cross-Linking Induces Accumulation of CD5 mRNA.- GP130 in Human Myeloma/Plasmacytoma.- Analysis of Antigen-Driven Positive and Negative Selection of Phosphocholine-Specific Bone Marrow B-Cells.- Growth Regulation — C-myc.- Role of the Rel-Family of Transcription Factors in the Regulation of c-myc Gene Transcription and Apoptosis of WEHI231 Murine B-Cells.- c-myc Transcription is Initiated From Po in 70% of Patients with Multiple Myeloma.- Clustered Mutations in the Transcritpional Activation Domainof Myc in 8q24 Translocated Lymphomas and their Functional Consequences.- Association with C-Myc: An Alternate Mechanism for c-Myc Function.- The Role of Ornithine Decarboxylase in c-Myc-lnduced Apoptosis.- Growth Factor Regulation of Cell Cycle Progression and Cell Fate Determination.- Growth Regulation: Apoptosis, BCL-2, Dormancy.- Defective Apoptosis due to Bcl-2 Overexpression May Explain Why B-CLL Cells Accumulate in G0.- Lyn Tyrosine Kinase Signals Cell Cycle Arrest in Mouse and Human B-Cell Lymphoma.- A Link Between the Antioxidant Defense System and Calcium: A Proposal for the Biochemical Function of Bcl-2.-Heterodimerization with Bax is Required for Bcl-2 to Repress Cell Death.- Growth Regulation: Cyclin D1, ABL.- Mantle Cell/Centrocytic Lymphoma: Molecular and Phenotypic Analysis Including Analysis of the bcl-1 Major Translocation Cluster by PCR.- Cyclin D1 as the Putative bcl-1 Oncogene.- Pre-B-Cells Transformed by ts Abelson Virus Rearrange ? and ? Genes in Early G1.- Development of btk Transgenic Mice.- Genomic Instability: General Topics.- Genomic Instability in B-Cells and Diversity of Recombinations That Activate c-myc.- Broken-Ended DNA and V(D)J Recombination.- Mutations in the Coding Region of c-myc Occur Independently of Mutations in the Regulatory Regions and are Predominantly Associated with myc/lg Translocation.- The Generation of Pvt-1/Ck Chimeric Transcripts as an Assay for Chromosomal Translocations in Mouse Plasmacytomas.- Interacisternal A-particle (IAP) Genes show Similar Patterns of Hypomethylation in Established and Primary Mouse Plasmacytomas.- Regulatory Elements in the Immunoglobulin Kappa Locus Induce c-myc Activation in Burkitt’s Lymphoma Cells.- Genomic Instability: Heavy Chain Switch Related Problems.- Illegitimate Recombinations Between c-myc and Immunoglobulin Loci Are Remodeled by Deletions in Mouse Plasmacytomas But Not in Burkitt’s Lymphomas.- Sy3 SNIP and SNAP Binding Motifs are Occupied in vivo in Mitogen Activated l.29? + Cells.- Chromosomally Integrated Retroviral Substrates are Sensitive Indicators of an Antibody Class Switch Recombinase-Like Activity.- The Role of BSAP in Immunoglobulin Isotype Switching and B-Cell Proliferation.