Congenital Cytomegalovirus Infection, 2011 Epidemiology, Diagnosis, Therapy
Coordonnateur : Baumann Gabriele
1 Long known, long ignored – a brief history of cytomegalovirus research
1.1 Beginnings: 1881–1914
1.2 Between the wars: 1914–1930
1.3 From 1930 to 1960
1.4 From 1960 to the present
References
2 Virus-host interaction for defence and transmission
2.1 The virus
2.2 The host
2.2.1 Cell types involved in replication and distribution
2.2.2 The immune system – strengths and weakness
2.2.3 The placenta – a barrier?
2.2.4 Cytomegalovirus – placenta – fetus: a slippery slope between defence and transmission
References
3 Epidemiology – the influence of socioeconomic differences
3.1 Infant mortality as a social mirror
3.2 One effect – many causes
3.2.1 Maternal aetiology
3.2.2 Foetal aetiology
3.2.3 Placental aetiology
3.3 Epidemiology of congenital CMV infection
3.3.1 Congenital CMV and virus strains
References
4 Prospects and obstacles of diagnosis
4.1 Screening for congenital CMV infection
4.1.1 Screening of the mother
4.1.2 Screening of the newborn
4.2 Diagnosis of congenital CMV infection
4.2.1 Prenatal diagnosis
4.2.2 Neonatal diagnosis
References
5 Clinical outcome: acute symptoms and sleeping hazards
Thorsten W. Orlikowsky
5.1 Relevance of connatal CMV infection for the paediatrician and neonatologist
5.2 The tip of the iceberg
5.3 Lucky chance by neonatal immune response
5.4 Features of symptomatic CMV infection
5.5 Timing of infection
5.6 Symptoms of the central nervous system in detail
5.6.1 Microcephaly5.6.2 Ocular defects
5.6.3 Hearing loss
5.6.4 Mental and psychomotor retardation
5.6.5 Seizures
5.7 Unspecific symptoms in detail
5.7.1 Temperature instability
5.7.2 Perfusion and rash
5.7.3 Lung
5.7.4 Liver
5.7.5 Jaundice
5.7.6 Spleen
5.7.7 Platelet system
5.7.8 Anaemia
5.7.9 Gastrointestinal tract
5.8 Asymptomatic infection
5.9 Differential diagnosis
References
6 Prevention and therapy – more than trial and error
6.1 Antivirals
6.1.1 Treatment of pregnant women
6.1.2 Treatment of neonates
6.2 Passive immunisation
6.3 Active immunisation (vaccination)
References
7 How to save money: congenital CMV infection and the economy
Evelyn Walter, Christine Brennig, Vera Schollbauer
7.1 Introduction
7.2 Methodology
7.2.1 Incidence-based approach
7.2.2 Cost calculation
7.2.3 Cost of sequelae
7.3 Cost of illness in Germany
7.3.1 Total societal costs
7.3.2 Sensitivity analysis
7.3.3 Impact through prevention
7.4 Discussion
References
Index
List of contributors
Latest scientific findings
Written in understandable manner
Informative overview on the topic
Socioeconomic factors are discussed
Date de parution : 10-2014
Ouvrage de 149 p.
15.5x23.5 cm
Date de parution : 12-2010
Disponible chez l'éditeur (délai d'approvisionnement : 15 jours).
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