Comprehensive Management of Arteriovenous Malformations of the Brain and Spine

Vascular malformations of the brain and spine pose many management challenges. This text provides a comprehensive, state-of-the-art review of the natural history, treatment options, and outcomes of patients with these conditions. Despite their relative rarity, these lesions are responsible for devastating injury to individuals and can cause an enduring physical, psychological, and economic burden on patients and families. Many new therapeutic options are now available with the advent of novel surgical, endovascular, and radiosurgical techniques. The basic sciences have fuelled development of small molecule and biologic therapies targeting the molecular basis of disease. Authored by international experts in the fields of neurosurgery, neurology, radiology, and radiation oncology, this book provides state-of-the-art treatment plans and discussions of ideal therapy. This text is aimed at practitioners in the fields of neurology, neurosurgery, neuroradiology, radiation oncology, rehabilitation medicine and allied fields who care for patients with brain and spinal vascular malformations.

Preface; Part I. Development, Anatomy, and Physiology of Arteriovenous Malformations of the Central Nervous System: 1. Development of the central nervous system vasculature and the pathogenesis of brain arteriovenous malformations; 2. Cranial vascular anatomy and implications for arteriovenous malformation and dural arteriovenous fistula treatment; 3. Spinal vascular anatomy and implications for treatment of arteriovenous malformations; 4. Physiology and hemodynamics of arteriovenous malformations; 5. Natural history of arteriovenous malformations and indications for treatment; Part II. Evaluation and Treatment Considerations for Arteriovenous Malformations: 6. Imaging evaluation of arteriovenous malformations; 7. Intraoperative evaluation of blood flow with indocyanine green videoangiography; 8. Neuromonitoring for arteriovenous malformation surgery; 9. Neuroanesthesia for treatment of arteriovenous malformations; 10. Classification of brain and spinal arteriovenous malformations and arteriovenous fistulas; Part III. Surgical Approaches to the Treatment of Arteriovenous Malformations: 11. Surgical approaches and nuances for supratentorial arteriovenous malformations; 12. Surgical approaches and nuances for arteriovenous malformations in the posterior fossa; 13. Surgical management of cerebral dural arteriovenous fistulas; 14. Surgery of spinal arteriovenous malformations and arteriovenous fistulas; 15. Surgery of basal ganglia, thalamic, and brainstem arteriovenous malformations; Part IV. Medical, Endovascular, and Radiosurgical Treatment of Arteriovenous Malformations: 16. Complications of arteriovenous malformation rupture and medical management of hemorrhage; 17. Endovascular treatment of supratentorial arteriovenous malformations; 18. Endovascular treatment of arteriovenous malformations of the posterior fossa; 19. Endovascular treatment of arteriovenous fistulas of the brain; 20. Endovascular management of vein of Galen malformations; 21. Endovascular treatment of spinal arteriovenous malformations and arteriovenous fistulas; 22. Radiosurgical basics for the treatment of arteriovenous malformations: indications and techniques; 23. Radiosurgery for brain arteriovenous malformations and arteriovenous fistulas; 24. Radiosurgery for spinal arteriovenous malformations and arteriovenous fistulas; 25. Multidisciplinary treatment of arteriovenous malformations; 26. Palliative treatment of inoperable arteriovenous malformations; 27. Pediatric arteriovenous malformations: special considerations; 28. Management of residual or recurrent arteriovenous malformations; Index.

Robert F. Spetzler, MD is the J. N. Harber Chairman of Neurological Surgery and Director of the Barrow Neurological Institute, Phoenix, AZ, USA.
Douglas S. Kondziolka, MD, MSc, FRCSC, FACS is Professor of Neurosurgery; Vice-Chair, Clinical Research (Neurosurgery); Professor of Radiation Oncology; and Director, Center for Advanced Radiosurgery, NYU Langone Medical Center, New York, NY, USA.
Randall T. Higashida, MD is Clinical Professor of Radiology, Neurological Surgery, Neurology, and Anesthesiology, and Chief of the Division of Interventional Neurovascular Radiology at the University of California San Francisco Medical Center, San Francisco, CA, USA.
M. Yashar S. Kalani, MD, PhD is Assistant Professor of Neurological Surgery at the Barrow Neurological Institute, Phoenix, AZ, USA.