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Clinical Epidemiology (2nd Ed., 2nd ed. 2015) Practice and Methods Methods in Molecular Biology Series, Vol. 1281

Langue : Anglais

Coordonnateurs : Parfrey Patrick S., Barrett Brendan J.

Couverture de l’ouvrage Clinical Epidemiology

Focusing on improving the diagnosis, prognosis, and management of human disease, this book takes on the issues of research design, measurement, and evaluation which are critical to clinical epidemiology. This second edition of Clinical Epidemiology: Practice and Methods opens with how best to frame a clinical research question, the ethics associated with doing a research project in humans, and the definition of various biases that occur in clinical research. From there, it continues by examining issues of design, measurement, and analysis associated with various research designs, including determination of risk in longitudinal studies, assessment of therapy in randomized controlled clinical trials, and evaluation of diagnostic tests, and then delves into the more specialized area of clinical genetic research, before concluding with basic methods used in evidence-based decision making including critical appraisal, aggregation of multiple studies using meta-analysis, health technology assessment, clinical practice guidelines, development of health policy, translational research, how to utilize administrative databases, and knowledge translation. Written for the highly successful Methods in Molecular Biology series, chapters include the kind of detail and practical advice to ensure real world success.

Comprehensive and authoritative, Clinical Epidemiology: Practice and Methods, Second Edition is intended to educate researchers on how to undertake clinical research and should be helpful not only to medical practitioners but also to basic scientists who want to extend their work to humans, to allied health professionals interested in scientific evaluation, and to trainees in clinical epidemiology.

Part I: Introduction

 

1. On Framing the Research Question and Choosing the Appropriate Research Design

            Patrick S. Parfrey and Pietro Ravani

 

2. Research Ethics for Clinical Researchers

            John D. Harnett and Richard Neuman

 

3. Definitions of Bias in Clinical Research

            Geoffrey Warden

 

Part II: Longitudinal Studies

 

4. Longitudinal Studies 1: Determination of Risk

            Sean W. Murphy

 

5. Longitudinal Studies 2: Modeling Data Using Multivariate Analysis

            Pietro Ravani, Brendan J. Barrett, and Patrick S. Parfrey

 

6. Longitudinal Studies 3: Data Modeling Using Standard Regression Models and Extensions

            Pietro Ravani, Brendan J. Barrett, and Patrick S. Parfrey

 

7. Longitudinal Studies 4: Matching Strategies to Evaluate Risk

            Matthew T. James

 

8. Longitudinal Studies 5: Development of Risk Prediction Models for Patients with Chronic Disease

            Navdeep Tangri and Claudio Rigatto

 

Part III: Randomized Controlled Clinical Trials

 

9. Randomized Controlled Trials 1: Design

            Bryan M. Curtis, Brendan J. Barrett, and Patrick S. Parfrey

 

10. Randomized Controlled Trials 2: Analysis

            Robert N. Foley

 

11. Randomized Controlled Trials 3: Measurement and Analysis of Patient-Reported Outcomes

            Michelle M. Richardson, Megan E. Grobert, and Klemens B. Meyer

 

12. Randomized Controlled Trials 4: Biomarkers and Surrogate Outcomes

            Claudio Rigatto and Brendan J. Barrett

 

13. Randomized Controlled Trials 5: Determining the Sample Size and Power for Clinical Trials and Cohort Studies

            Tom Greene

 

14. Randomized Controlled Trials 6: On Contamination and Estimating the Actual Treatment Effect

            Patrick S. Parfrey

 

15. Randomized Controlled Trials 7: Analysis and Interpretation of Quality of Life Scores

            Robert N. Foley and Patrick S. Parfrey

 

16. Randomized Controlled Trials 8: Planning, Monitoring, and Execution

            Elizabeth Hatfield, Elizabeth Dicks, and Patrick S. Parfrey

 

Part IV: The Basics for Other Clinical Epidemiology Methods

 

17. Evaluation of Diagnostic Tests

            John M. Fardy and Brendan J. Barrett

 

18. Qualitative Research in Clinical Epidemiology

            Deborah M. Gregory and Christine Y. Way

 

19. Health Economics in Clinical Research

            Braden J. Manns

 

Part V: Clinical Genetic Research

 

20. Clinical Genetic Research 1: Bias

            Susan Stuckless and Patrick S. Parfrey

 

21. Clinical Genetic Research 2:  Genetic Epidemiology of Complex Phenotypes

            Darren D. O’Rielly and Proton Rahman

 

22. Clinical Genetic Research 3: Genetics ELSI (Ethical, Legal and Social Issues) Research

            Daryl Pullman and Holly Etchegary

 

Part VI: Methods in Evidence–Based Decision Making

 

23. Evidence-Based Decision Making 1: Critical Appraisal

            Laurie K. Twells

 

24. Evidence-Based Decision Making 2: Systematic Reviews and Meta-Analysis

            Aminu Bello, Natasha Wiebe, Amit Garg, and Marcello Tonelli

 

25. Evidence-Based Decision Making 3: Health Technology Assessment

            Daria O’Reilly, Kaitryn Campbell, Meredith Vanstone, James M. Bowen, Lisa Schwartz, Nazila Assasi, and Ron Goeree

 

26. Evidence-Based Decision Making 4: Development and Limitations of Clinical Practice Guidelines

            Bruce Culleton

 

27. Evidence-Based Decision-Making 5: Translational Research

            Deborah M. Gregory and Laurie K. Twells

 

28. Evidence-Based Decision Making 6: Utilization of Administrative Databases for Health Services Research

            Turin Chowdury and Brenda Hemmelgarn

 

29. Evidence-Based Decision Making 7: Knowledge Translation

            Braden J. Manns

 

30. Evidence-Based Decision Making 8: Health Policy, A Primer for Researchers

            Victor Maddalena

Includes cutting-edge techniques involving clinical research

Provides step-by-step detail essential for reproducible results

Contains key notes and implementation advice from the experts

Includes supplementary material: sn.pub/extras

Date de parution :

Ouvrage de 533 p.

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Prix indicatif 163,51 €

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Date de parution :

Ouvrage de 533 p.

17.8x25.4 cm

Disponible chez l'éditeur (délai d'approvisionnement : 15 jours).

232,09 €

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