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Chemistry and Biology of Serpins, 1997 Advances in Experimental Medicine and Biology Series, Vol. 425

Langue : Anglais

Coordonnateurs : Church Frank C., Cunningham Dennis D., Ginsburg David, Hoffman Maureane R., Stone Stuart R., Tollefsen Douglas M.

Couverture de l’ouvrage Chemistry and Biology of Serpins
Proceedings of an International Symposium held in Chapel Hill, North Carolina, April 13-16, 1996
I. Introduction.- 1. Serpins: From the Way It Was to the Way It Is.- 2. Serpins: A Mechanistic Class of Their Own.- II. Coagulation.- 3. Antithrombin: A Bloody Important Serpin.- 4. Heparin Cofactor II.- 5. PCI: Protein C Inhibitor?.- 6. Molecular Basis for the Resistance of Fibrin-Bound Thrombin to Inactivation by Heparin/Serpin Complexes.- III. Neurobiology and Cancer.- 7. Regulation of Neurons and Astrocytes by Thrombin and Protease Nexin-1: Relationship to Brain Injury.- 8. Maspin: A Tumor Suppressing Serpin.- 9. Proteases and Protease Inhibitors in Tumor Progression.- IV. Fibrinolysis.- 10. The Role of Reactive-Center Loop Mobility in the Serpin Inhibitory Mechanism.- 11. Substrate Specificity of Tissue Type Plasminogen Activator.- 12. Plasminogen Activator Inhibitor Type-2: A Spontaneously Polymerizing Serpin that Exists in Two Topological Forms.- 13. Of Mice and Men: The Function of Plasminogen Activator Inhibitors (PAIs) in Vivo.- V. Development and Reproduction.- 14. Biology of Progesterone-Induced Uterine Serpins.- 15. Serpins from an Insect, Manduca sexta.- 16. The Significance of Serpins in the Regulation of Proteases in the Male Genital Tract.- VI. Inflammation.- 17. Serpins and Programmed Cell Death.- 18. C 1 Inhibitor: Functional Analysis of Naturally-Occurring Mutant Proteins.- 19. Serp-1, a Poxvirus-Encoded Serpin, Is Expressed as a Secreted Glycoprotein that Inhibits the Inflammatory Response to Myxoma Virus Infection.- 20. Dysfunctional Variants and the Structural Biology of the Serpins.- VI. Noninhibitor Serpins.- 21. Structure-Function Studies on PEDF: A Noninhibitory Serpin with Neurotrophic Activity.- 22. Colligin, a Collagen Binding Serpin.- VII. Abstracts.- Coagulation, Neurobiology, and Cancer.- Fibrinolysis, Development, and Reproduction.- Inflammation and Noninhibitor Serpins.- Contributors.

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