Chemical Carcinogenesis 2, Softcover reprint of the original 1st ed. 1991 Modulating Factors

"chemical carcinogenesis" is the general title of the series of international meetings which are held, biannually, in sardinia (Italy) since 1981. Despite the generality of the title, the main effort of the scientific Committee has been to pursue a coherent line around one of the most distinguishing features of carcinogenesis: the "multifasic" development of the process. Given that many chemical compounds are known to cause "experimental cancer", many questions still remain unresolved or are given too simplistic answers. The very first question concerning the interaction between the chemical carcinogen and the molecular target in the cell is a debatable one despite the overwhelming literature in this field. It is certain that chemical carcinogens are toxic to cells and cause DNA damage: however it is still an open question as to how to relate these changes to the different stages of carcinogenesis including initiation. We have not to forget that 1/3 to 2/3 of the average life time of a given species elapses between the experimental administration of the carcinogen and the appearance of "cancer". The experimental manipulation of carcinogenesis through the use of "adequate biological models" has not simplified the problems about cancer, but it has led us to face the complexity of otherwise elementary biological properties, cell proliferation and differentiation. The understanding of this biological complexity is not just theoretical, but it may give us those adequate conceptual tools to approach "cancer" also from a medical point of view.

Nuclear Oncogenes as Transcription Factors.- Control of Hepatocyte Growth by Positive and Negative Growth Regulators and Mitogenic Triggers: Implications for Hepatic Neoplasia.- Cell Cycle Dependent Regulation of Poly(ADP-Ribose) Polymerase Gene Expression.- Different Expression of Cell Cycle Related Genes During Liver Regeneration and Liver Hyperplasia.- S-Adenosylmethionine Content, DNA Methylation and Gene Expression in Regenerating Liver.- Gene Activation and Deactivation During Multistage Hepatocarcinogenesis in the Rat.- Biochemical and Molecular Perturbations Induced in Preneoplastic Tissue by a S-Adenosyl-L-Methionine Load.- Alterations of Cell Surface Receptors and Expression of Cellular Oncogenes in the Liver of Rats Fed a Hypolipidemic Peroxisome Proliferator.- Growth Hormone-Regulated Expression of c-myc Gene During sex-Differentiated Promotion of Rat Liver Carcinogenesis.- In Situ Hybridization of Ha-Ras During Rat Liver Carcinogenesis.- Mutations in the H-Ras Proto-Oncogene in Early Precancerous Liver Lesions of the B6C3F1 Mouse.- Transformation of Human Epithelial Cells by Recombinant Human Papillomavirus DNA Associated with Cervical Cancer.- Cancer Families and Susceptibility to Cancer.- Cancer Syndromes in Humans.- Case-Control Studies on Cancer Risk in G6PD-Deficient Male Populations.- Genetic Susceptibility to Murine Hepatocarcinogenesis.- MHC-Linked Genes Controlling Growth and Reproduction Influence the Susceptibility to Diethylnitrosamine-Induced Carcinogenesis.- Metabolic Aberrations and Metamorphosis During Chemical Carcinogenesis.- Persistent Rat Liver Nodules Differ from Normal Liver, Regenerating Liver and Early Nodules both in Terms of Proteins of the Nuclear Matrix and Chromatin Condensation.- Intracellular Na+, K+, H+ and Cl? Activities and Membrane Potentials During the 4-Dimethylaminoazobenzene-Induced Rat Hepatocarcinogenesis.- Analysis of the Effects of Modifying Agents on Proliferation and Enzyme Phenotype in Focal Preneoplastic and Neoplastic Liver Lesions in Rats.- Epidermal Growth Factor-Induced Cell Proliferation and EGF Binding in Preneoplastic Foci in The Rat Liver.- The Different Calcium Requirements of the Mitogenic Effects Elicited in Primary Neonatal Rat Hapatocytes by the Diterpene Phorbol Esters 12-O-Tetradecanoylphorbol-13-Acetate and Sapintoxin A.- Glucose-6-Phosphate Dehydrogenase Molecular Forms in Different Experimental Models of Hepatic Cell Proliferation.- Estrogen Dependent Growth of a Rat Pituitary Tumor (MtT/F84).- Deterministic Coupling Between Cellular Bioenergetics, Cholesterol Synthesis, cell Proliferation and Cancer.- Dolichyl Phosphate as a Regulator of Cell Growth.- Regulation of Cholesterol Metabolism in Normal and Malignantly Transformed Tissue in Vivo.- Cholesterol Metabolism and Proliferative Processes.- Serum LCAT and Lipid Levels in grc-- Bearing Rats with Liver Cancer.- Covalent Modification of Proteins by Farnesol and the Control of Cell Proliferation.- Repeated Treatments with a Low HNE Concentration Affect K562 Cell Proliferation.- Arachidonic Acid Enrichment Augments the Malonildialdehyde Production in Yoshida AH-130 Hepatoma Cells.- Modulation of Phosphatidylinositol-4,5-Diphosphate (PIP2)-Phospholipase C Activity by 4-Hydroxyalkenals.- The Role of Hepatic Metabolism in Sex Differentiation of Chemical Hepatocarcinogenesis in the Rat.- Changes of Rat Liver Glutathione Peroxidase, Glutathione Reductase and Glutathione Transferase 7–7 by Lead Nitrate Treatment.- High Affinity P-450 Form for the Metabolic Activation of DEN in Liver of Acetone-Induced Rats but not of Hamsters.- Genotoxicity of Chloroethanes and Structure Activity Relationships.- Genetical and Biochemical Studies on Three Halogenated Ethanes.- “In Vivo” Interaction of Methionine and Cysteine Sulfur with Rat Liver tRNA.- Synthesis and Secretion of Cathepsin D in Normal And Tumor Human Cells.- Relationship Between Cell Proliferation and Cell Death.- An in Vitro Model for Apoptosis: Uptake and Degradation of Apoptotic Bodies.- Protein Catabolism and Apoptosis in AH-130 Hepatoma Cells and in the Host Rat Liver.- Protein synthesis During Programmed (Physiological) Cell Death.- Role of Tissue Transglutaminase in the Formation of Apoptotic Bodies.- The Induction of Apoptosis in Human Malignant Keratinocytes by Antisense DNA to Retinoid Receptors: Keys to the Function of Apoptosis and Vitamin A.- Cell Death and Cell Proliferation in Experimental Hepatocarcinogenesis.- Cell Death and Proliferation in Opisthorchis Viverrini-DHPN Induced Carcinogenesis in the Syrian Hamster Hepato-Pancreatic Axis.- Ethionine-Induced Atrophy of Rat Parotid Glands Involves Apoptosis of Acinar Cells: Implications for Chemical Carcinogenesis.- Apoptotic Effect of Skin Tumor Promoters on Thymocytes: Cell Death as a Possible Trigger for the Induction of Promotability (Conversion).- Chemoprevention of Rat Liver Carcinogenesis by S-Adenosylmethionine: Role of Remodeling and Apoptosis.- The Occurrence of Apoptosis in Tumors and its Effect on Neoplastic Development.- Stimulus Dependent Phenotypic Diversity in the Resistant Hepatocyte Model.- Effects of 5-Azacytidine (5-AzC), 5-Bromodeoxyuridine (Brdu) and Diethyldithiocarbamate (DEDTC) on Diethylnitrosamine (DEN)-Induced Carcinogenesis in Rats.- Modulation by a Choline Devoid Diet of Repair of Chemical Damage in Liver DNA.- Is the Beta-Blocker DL-Zami 1305 a Tumor Promoter for Rat Liver?.- Amplifying Effects of uracil on Multi-stage Bladder Carcinogenesis in Rats.- Bombesin and Hepatocyte Proliferation.- Inhibition of Growth of Breast Cancer in Vitro by the Ribosome-Inactivating Protein Saporin 6.- Determination of PAH-DNA Adducts in Lung Tissue of Cancer Patients.- Theoretical Studies of Flavone Acetic Acids.