Preface; Part I. Classification, Pathology and Basic Aspects: 1. Definition and classification of small vessel diseases Leonardo Pantoni; 2. Pathology of cerebral small vessel disease Jun Ogata, Hiromichi Yamanishi and Hatsue Ishibashi-Ueda; 3. Pathological aspects of the ischemic consequences of small vessel disease on brain parenchyma Margaret Esiri and Elisabet Englund; 4. Pathological aspects of the hemorrhagic consequences of small vessel diseases on the brain Johannes Attems and Kurt A. Jellinger; 5. Experimental animal models of cerebral small vessel disease Atticus H. Hainsworth and Hugh S. Markus; 6. Sporadic small vessels disease: pathogenic aspects Joanna M. Wardlaw and Leonardo Pantoni; 7. Pathogenic aspects of hereditary small vessel disease of the brain Anne Joutel; 8. Hereditary cerebral small vessel disease and role of genetic factors Christian Opherk and Martin Dichgans; 9. The link between large artery aging and cerebral small vessel disease Angelo Scuteri and Edward G. Lakatta; 10. The neurovascular unit and possible influences on cerebral small vessel disease Gregory J. del Zoppo, Yoshikane Izawa and Brian T. Hawkins; Part II. Neuroimaging and Laboratory Aspects: 11. Conventional brain imaging of white matter lesions Franz Fazekas, Christian Enzinger, Stefan Ropele and Reinhold Schmidt; 12. Conventional imaging of lacunar infarcts Eric Jouvent and Hugues Chabriat; 13. Imaging of hemorrhagic cerebral small vessel disease Jennifer Linn, Steven Greenberg and Anand Viswanathan; 14. Nonconventional MR techniques for imaging cerebral small vessel disease David Nyenhuis and Glenn T. Stebbins; 15. Cerebral hemodynamics in cerebral small vessel disease Hugh S. Markus, Charlotte L. Allan and Klaus P. Ebmeier; 16. Markers of endothelial dysfunction, oxidative stress and inflammation in cerebral small vessels disease Francesca Pescini and Rosanna Abbate; 17. Cerebral small vessel disease: cerebrospinal fluid aspects Anders Wallin and Maria Bjerke; Part III. Clinical Aspects of Cerebral Small Vessel Disease: 18. Acute stroke syndromes caused by small vessel disease Mark I. Boulos, Ranjith K. Menon, Richard I. Aviv, Sandra E. Black and Richard H. Swartz; 19. Cognitive consequences of cerebral small vessel disease José M. Ferro, Ana Verdelho and Sofia Madureira; 20. Motor, stance and balance consequences of cerebral small vessel diseases H. Baezner, Christian Blahak and Michael G. Hennerici; 21. Psychiatric consequences of small vessel disease Perminder S. Sachdev and Sharon Reutens; 22. Consequences of cerebral small vessel disease: disability, mortality and prognosis Anna Poggesi, Leonardo Pantoni and Domenico Inzitari; 23. Clinical aspects of genetic forms of small vessel disease Maria Teresa Dotti and Antonio Federico; 24. Interaction between cerebral small vessel disease and neurodegenerative changes Wiesje M. van der Flier and Raj Kalaria; Part IV. Therapeutic Aspects: Prevention, Future Directions, and Possibilities: 25. Risk factors as possible targets for prevention of small vessel disease Vincent Mok, Philip B. Gorelick and Christopher Chen; 26. Treatment approaches for lacunar strokes Makoto Nakajima, Thalia Field and Oscar R. Benavente; 27. Cerebral small vessels disease imaging as a surrogate marker for clinical trials Reinhold Schmidt, Margherita Cavalieri and Marisa Loitfelder; 28. Cerebral small vessel disease: a look to the future Philip B. Gorelick and Leonardo Pantoni; Index.