Cellular Adhesion, Softcover reprint of the original 1st ed. 1994 Molecular Definition to Therapeutic Potential New Horizons in Therapeutics Series

The books in this acclaimed series provide integrated, critical surveys of topics of current interest to the pharmaceutical industry. Cellular Adhesion: Molecular Definition to Therapeutic Potential covers the molecular definition of adhesion molecule structure and function, the biological consequences of cellular adhesion, and the therapeutic potential of targeting adhesion molecules.

I. Molecular Definition—Adhesion Molecule Structure and Function.- 1 The Biological Function of ?3 Integrins and Other Vitronectin Receptors.- 2 Integrin Modulating Factor and the Regulation of Leukocyte Integrins.- 3 Structure-Function Aspects of Selectin-Carbohydrate Interactions.- 4 Recognition of Cell Surface Carbohydrates by C-Type Animal Lectins.- 5 The Uvomorulin-Catenin Complex: Insights into the Structure and Function of Cadherins.- 6 Cytotactin: A Substrate Adhesion Molecule with Amphitropic Functions in Morphogenesis.- 7 Adhesion Molecules and Bone Remodeling.- II. Biological Consequences of Cellular Adhesion.- 8 Effects of Shear Stress on Leukocyte Adhesion.- 9 Blockade of Leukocyte Adhesion in in Vivo Models of Inflammation.- 10 Proadhesive Cytokine Immobilized on Endothelial Proteoglycan: A New Paradigm for Recruitment of T Cells.- 11 Lung Inflammation and Adhesion Molecules.- 12 Adhesion Molecule-Dependent Cardiovascular Injury.- 13 GPIIb/IIIa Antagonists as Novel Antithrombotic Drugs: Potential Therapeutic Applications.- III. Targeting Adhesion Molecules—Therapeutic Potential.- 14 The Pathological Consequences of Bacterial Adhesion to Medical Devices: A Practical Solution to the Problem of Device-Related Infections.- 15 Peptide Mimetics as Adhesion Molecule Antagonists.- 16 Derivation of Therapeutically Active Humanized and Veneered Anti-CD18 Antibodies.

The book in this acclaimed series provides integrated, critical surveys of topics of current interest to the pharmaceutical industry. It covers the molecular definition of adhesion molecule structure and function, the biological consequences of cellular adhesion, and the therapeutic potential of targeting adhesion molecules.