Cardiac Regeneration and Repair Biomaterials and Tissue Engineering Woodhead Publishing Series in Biomaterials Series

Cardiac Regeneration and Repair, Volume Two reviews the use of biomaterials, alone or combined with cell therapy, in providing tissue-engineered constructs to repair the injured heart and prevent or reverse heart failure.

Part one explores the variety of biomaterials available for cardiac repair, including nanomaterials and hydrogels. Further chapters explore the use of biomaterials to enhance stem cell therapy for restoring ventricular function and generating stem cell-modified intravascular stents. Part two focuses on tissue engineering for cardiac repair, including chapters on decellularized biologic scaffolds, synthetic scaffolds, cell sheet engineering, maturation of functional cardiac tissue patches, vascularized engineered tissues for in vivo and in vitro applications, and clinical considerations for cardiac tissue engineering. Finally, part three explores vascular remodeling, including chapters highlighting aortic extracellular matrix remodeling, cell-biomaterial interactions for blood vessel formation, and stem cells for tissue-engineered blood vessels.

Cardiac Regeneration and Repair, Volume Two is complemented by an initial volume covering pathology and therapies. Together, the two volumes of Cardiac Regeneration and Repair provide a comprehensive resource for clinicians, scientists, or academicians fascinated with cardiac regeneration, including those interested in cell therapy, tissue engineering, or biomaterials.

• Contributor contact details
• Woodhead Publishing Series in Biomaterials
• Foreword
• Introduction
• Part I: Biomaterials for cardiac regeneration and repair
  • Chapter 1: Nanotechnology and nanomaterials for cardiac repair
    • Abstract:
    • 1.1 Introduction
    • 1.2 Electrospinning nanofibrous scaffolds
    • 1.3 Conductive nanomaterial for myocardial infarction (MI)
    • 1.4 Nanomedicine
    • 1.5 Future trends
  • Chapter 2: Hydrogels for cardiac repair
    • Abstract:
    • 2.1 Introduction
    • 2.2 Hydrogels
    • 2.3 Injectable hydrogels alone for cardiac repair
    • 2.4 Hydrogels as a platform for co-delivery
    • 2.5 Delivery strategies of hydrogels
    • 2.6 Future trends
    • 2.7 Sources of further information and advice
  • Chapter 3: Injectable biomaterials for cardiac regeneration and repair
    • Abstract:
    • 3.1 Introduction
    • 3.2 Design criteria for biomaterials in cardiac tissue engineering
    • 3.3 Injectable biomaterials
    • 3.4 Bioactive molecules used in cardiac tissue engineering
    • 3.5 Hydrogels to promote endogenous cardiac regeneration and repair
    • 3.6 Hydrogels for the delivery of cells for cardiac regeneration
    • 3.7 Hydrogels for the artificial maintenance of ventricle geometry and repair
    • 3.8 Future trends
  • Chapter 4: Biomaterials for enhancing endothelial progenitor cell (EPC) therapy for cardiac regeneration
    • Abstract:
    • 4.1 Introduction
    • 4.2 Endothelial progenitor cells (EPCs)
    • 4.3 Enhancing EPC therapy
    • 4.4 Future trends
    • 4.5 Conclusion
  • Chapter 5: Endothelial progenitor cell (EPC)-seeded intravascular stents
    • Abstract:
    • 5.1 Intravascular stents
    • 5.2 Endothelial progenitor cells (EPCs)
    • 5.3 EPC-seeded intravascular stents
    • 5.4 Conclusion
    • 5.5 Sources of further information and advice
• Part II: Tissue engineering for cardiac regeneration and repair
  • Chapter 6: Biomaterials and cells for cardiac tissue engineering
    • Abstract:
    • 6.1 Introduction
    • 6.2 Cardiac structure
    • 6.3 Cardiac remodeling in myocardial infarction (MI)
    • 6.4 Cells for cardiac tissue engineering
    • 6.5 Materials for cardiac tissue engineering
    • 6.6 Creation of heart tissue using cell and biomaterials: an in vitro approach
    • 6.7 Creation of heart tissue using cell and biomaterials: an in vivo approach of injectable matrices
    • 6.8 Vascularization in myocardial tissue engineering
    • 6.9 Ventricular aneurysm repair using cells and biomaterials
    • 6.10 Clinical applications
    • 6.11 Conclusion and future trends
  • Chapter 7: Decellularized biological scaffolds for cardiac repair and regeneration
    • Abstract:
    • 7.1 Introduction
    • 7.2 Methods of bioscaffold preparation
    • 7.3 Cardiac repair with non-cardiac bioscaffolds
    • 7.4 Tissue specificity of extracellular matrix bioscaffolds
    • 7.5 Current methods for decellularizing cardiac tissue
    • 7.6 Whole organ engineering
  • Chapter 8: Biomaterial scaffolds for cardiac regeneration and repair derived from native heart matrix
    • Abstract:
    • 8.1 Heart failure and cardiac tissue engineering
    • 8.2 Extracellular matrix (ECM) as a biomaterial
    • 8.3 Cardiac ECM as a scaffold for cardiac tissue engineering
    • 8.4 Hybrid scaffolds for cell delivery into the heart
    • 8.5 Native heart ECM hydrogels for cardiac differentiation
    • 8.6 Current limitations and future trends
    • 8.7 Acknowledgments
  • Chapter 9: Cell sheet engineering for cardiac repair and regeneration
    • Abstract:
    • 9.1 Introduction
    • 9.2 Skeletal myoblasts
    • 9.3 Cardiac progenitor cells and cardiac stem cell sheets
    • 9.4 Other tissue stem/progenitor cells and cell sheets
    • 9.5 Pulsatile cardiac cell sheet and transplantation into animal models
    • 9.6 Cardiac differentiation from human embryonic stem cells (ESCs)/induced pluripotent stem cells (iPSCs)
    • 9.7 Engineered cardiac tissue using ESC/iPSC-derived cardiomyocytes
    • 9.8 Future trends
    • 9.9 Conclusion
    • 9.10 Acknowledgements
  • Chapter 10: Maturation of functional cardiac tissue patches
    • Abstract:
    • 10.1 Introduction
    • 10.2 Native cardiac development
    • 10.3 Engineering and functional maturation of biomimetic cardiac tissues
    • 10.4 Promoting the maturation of cardiac tissue patches
    • 10.5 MicroRNAs
    • 10.6 Pluripotent stem cells and their associated molecular effectors
    • 10.7 Mechanical forces and stiffness in cardiac tissue engineering
    • 10.8 Conclusions and future trends
    • 10.9 Acknowledgements
  • Chapter 11: Vascularizing engineered tissues for in vivo and in vitro applications
    • Abstract:
    • 11.1 Introduction
    • 11.2 Strategies to vascularize engineered tissues
    • 11.3 In vitro applications
    • 11.4 In vivo applications
    • 11.5 Major barriers and future trends
    • 11.6 Conclusion
  • Chapter 12: Clinical considerations for cardiac tissue engineering
    • Abstract:
    • 12.1 Introduction
    • 12.2 Heart muscle engineering concepts and applications
    • 12.3 Cell types for clinical translation
    • 12.4 Extracellular matrix from within or outside
    • 12.5 In vivo studies in large animal models
    • 12.6 Clinical translation
    • 12.7 Future trends
    • 12.8 Sources of further information and advice
    • 12.9 Acknowledgements
• Part III: Vascular remodelling for regeneration and repair
  • Chapter 13: Aortic extra cellular matrix (ECM) remodeling
    • Abstract:
    • 13.1 Introduction
    • 13.2 The aorta
    • 13.3 Pathophysiological changes in thoracic aortic aneurysm (TAA) development
    • 13.4 Extracellular matrix (ECM) remodeling
    • 13.5 Protease activity
    • 13.6 Regulation of protease activity
    • 13.7 Challenges and pitfalls of clinical therapy
    • 13.8 Conclusion
  • Chapter 14: Cell–biomaterial interactions for blood vessel formation
    • Abstract:
    • 14.1 Introduction
    • 14.2 Blood vessel architecture
    • 14.3 Matrices to investigate vasculogenesis mechanisms
    • 14.4 Matrices to direct in vitro prevascularization
    • 14.5 Scaffolds to induce and study angiogenesis
    • 14.6 Manipulating materials to guide vascular assembly and formation
    • 14.7 Future trends
    • 14.8 Conclusion
  • Chapter 15: Stem cells in tissue-engineered blood vessels for cardiac repair
    • Abstract:
    • 15.1 Introduction
    • 15.2 Development of biodegradable tissue-engineered vascular grafts (TEVGs)
    • 15.3 Techniques for in vivo experiments and evaluation
    • 15.4 Clinical application of TEVGs
    • 15.5 Future trends
    • 15.6 Sources of further information and advice
  • Chapter 16: Tissue-engineered cardiovascular grafts and novel applications of tissue engineering by self-assembly (TESA™)
    • Abstract:
    • 16.1 Introduction
    • 16.2 Clinical setting
    • 16.3 Current options and the need for alternative conduits
    • 16.4 Evolution of cardiovascular tissue engineering
    • 16.5 Tissue engineering by self-assembly (TESA™): a scaffold-free technology
    • 16.6 Clinical results with TESA™ technology
    • 16.7 Future trends
• Index

• Surveys the variety of biomaterials available for cardiac repair, including nanomaterials and hydrogels.
• Focuses on tissue engineering for cardiac repair including clinical considerations for cardiac tissue engineering
• Explores vascular remodeling, highlighting aortic extracellular matrix remodeling, cell-biomaterial interactions for blood vessel formation, and stem cells for tissue-engineered blood vessels