Calmodulin and Intracellular Ca++ Receptors, Softcover reprint of the original 1st ed. 1982

This volume is a collection of papers contributed by partici­ pants in the Symposium on Recent Advances in Ca++ and Cell Function, Calmodulin and Intracellular Ca++ Receptors, held in Kyoto, Japan, July 25-29, 1981. This meeting was one of the satellite symposia to the 8th International Congress of Pharmacology (Tokyo, 1981). Calcium ion is a well known intracellular messenger. Since troponin and calmodulin were found to be intracellular medi­ ators of a number of actions of Ca++, the functions of this ion, with relevance to its intracellular receptive proteins, have received a great deal of attention from workers in the fields of biochemistry, biology, pharmacology, physiology, endocrinology, clinical medicine, and related fields. The symposium was designed to illuminate new aspects of this rapidly growing field of research and extensive discus­ sions on various topics were carried out. This volume contains all the papers presented plus the abstracts of the Poster Presentations. Both researchers and students should find the data and references of considerable value in their studies. We gratefully acknowledge the sponsorship of the Committees of the 8th International Congress of Pharmacology and the Yamada Science Foundation. We also thank Dr. S. Akabori for his encouragement and support. Special thanks are extented to Ms. S. Ikukawa, Ms. A. Yoshikawa, M. Ohara and all our colleagues who contributed much to the symposium. We also extend our appreciation to Mrs. F. Comes and Patricia M. Vann for the editing and preparation of the manuscript in its final form.

Molecular Basis of Calmodulin Function.- The Pharmacology of Calmodulin Antagonism: A Reappraisal.- Biopharmacological Assessment of Calmodulin Function: Utility of Calmodulin Antagonists.- Intracellular Localization of Calmodulin Antagonist, W-7.- Possible Dual Regulatory Mechanism in Smooth Muscle Actomyosin.- Ion Binding to Calmodulin.- Structure and Ca++ Dependent Conformational Change of Calmodulin.- Guanine Nucleotide Dependence of Calcium-Calmodulin Stimulation of Adenylate Cyclase in Rat Cerebral Cortex and Striatum.- Patterns of Intracellular Ca++ Distribution and Mobilization in Smooth Muscle.- Role of Ca++-Calmodulin in Metabolic Regulation in Plants.- Regulation of Calmodulin in Mammalian Cells.- Calcium and Calmodulin Dependent Regulation of Microtubule Assembly.- Calmodulin and Cytoskeleton.- Effect of the Calmodulin-Caldesmon System on the Physical State of Actin Filaments.- Mode of Calcium Binding to Smooth Muscle Contractile System.- Kinetic Studies of the Activation of Cyclic Nucleotide Phosphodiesterase by Ca++ and Calmodulin.- Ca++ and Protein Phosphorylation.- The Regulation of Myosin Light Chain Kinase by Ca++ and Calmodulin in vitro and in vivo.- Phosphorylation and ATPase Activity of Smooth Muscle Myosin.- Demonstration of Two Types of Ca++ Dependent Protein Kinases in the Brain and Other Tissues.- Calmodulin Dependent Protein Kinases from Rat Brain.- A Highly Active Calcium Ion Stimulated Endogenous Protein Kinase in Myelin: Kinetic and Other Characteristics, Calmodulin Dependence and Comparison with Other Brain Kinase(s).- Interaction of Calmodulin with cAMP Dependent Protein Kinase in Brain.- Regulation of Contractile Proteins in Smooth Muscle and Platelets by Calmodulin and Cyclic AMP.- Two Transmembrane Control Mechanisms for Protein Phosphorylation in Bidirectional Regulation of Cell Functions.- Ca++ Regulation of Microfilament System.- Calcium Regulation in Amoeboid Movement.- Actinogelin: A Calcium Sensitive Regulator of Microfilament System.- Calcium Regulation of Actin Network Structure by Gelsolin.- Physical Properties of Fragmin, A Ca++ Sensitive Regulatory Protein of Actin Polymerization Isolated from Physarum Plasmodium.- Closing.- Calcium Ion and Calcium Binding Proteins.- Participants.- Contributor Index.