Biomechanics, Softcover reprint of the original 1st ed. 1996 Functional Adaption and Remodeling

"Function dictates structure" is a classic paradigm reaffirmed in Wolff's law of the skeletal system. A major question being addressed by current research in biomechanics is whether this doctrine also holds true for the cardiovascular system and connective tissues. Taking a multidisciplinary approach to this question has produced new insights into the sensors, signals, and activators that produce remodeling and functional adaptation in cardiac muscle, blood vessels, and bone, including important new findings on the response of vascular endothelial cells to shear stress. Other work focuses on the extent of remodeling and adaptation processes in tendons, ligaments, and intervertebral discs. Together with two companion volumes, Computational Biomechanics and the Data Book on Mechanical Properties of Living Cells, Tissues,and Organs, this monograph will prove invaluable to those working in fields ranging from medical science and clinical medicine to biomedical engineering and applied mechanics.

Response of Endothelial Cells to Mechanical Stress.- Response of Vascular Endothelial Cells to Flow Shear Stress: Phenomenological Aspect.- Responses of Vascular Endothelial Cells to Fluid Shear Stress: Mechanism.- Functional Adaptation and Optimal Control of the Heart and Blood Vessels.- Responses of the Heart to Mechanical Stress.- Residual Stress in the Left Ventricle.- Response of Arterial Wall to Hypertension and Residual Stress.- Tissue Remodeling and Biomechanical Response in Orthopedics and Orthodontics.- Mechanical Stresses and Bone Formation.- Fatigue Fracture Mechanism of Cancellous Bone.- Residual Stress in Bone Structure: Experimental Observation and Model Study with Uniform Stress Hypothesis.- Response of Knee Joint Tendons and Ligaments to Mechanical Stress.- Remodeling of Tendon Autograft in Ligament Reconstruction.- Instability of the Spinal System with Focus on Degeneration of the Intervertebral Disc.- Biological Response in Orthodontics.