Basic Clinical Radiobiology (5th Ed.)
Coordonnateurs : Joiner Michael C., van der Kogel Albert J.
Basic Clinical Radiobiology is a concise but comprehensive textbook setting out the essentials of the science and clinical application of radiobiology for those seeking accreditation in radiation oncology, clinical radiation physics, and radiation technology.
Fully revised and updated to keep abreast of current developments in radiation biology and radiation oncology, this fifth edition continues to present in an interesting way the biological basis of radiation therapy, discussing the basic principles and significant developments that underlie the latest attempts to improve the radiotherapeutic management of cancer.
This new edition is highly illustrated with attractive 2-colour presentation and now includes new chapters on stem cells, tissue response and the convergence of radiotherapy, radiobiology, and physics. It will be invaluable for FRCR (clinical oncology) and equivalent candidates, SpRs (and equivalent) in radiation oncology, practicing radiation oncologists and radiotherapists, as well as radiobiologists and radiotherapy physicists.
Introduction: The significance of radiobiology and radiotherapy for cancer treatment. Irradiation-induced damage and the DNA damage response. Cell death after irradiation: How, when and why cells die. Quantifying cell kill and cell survival. Radiation dose-response relationships. Linear energy transfer and relative biological effectiveness. Physics of radiation therapy for the radiobiologist. Tumour growth and response to radiation. Fractionation: The linear-quadratic approach. The linear-quadratic approach in clinical practice. Modified fractionation. Time factors in normal tissue responses to irradiation. The dose-rate effect. Pathogenesis of normal tissue side effects. Stem cells in radiotherapy. Normal tissue tolerance and the effect of dose inhomogeneities. The oxygen effect and therapeutic approaches to tumour hypoxia. The tumour microenvironment and cellular hypoxia responses. Combined radiotherapy and chemotherapy. Molecular targeted agents for enhancing tumour response. Biological individualisation of radiotherapy. Molecular image guided radiotherapy. Retreatment tolerance of normal tissues. Biological response modification of normal tissue reactions: Basic principles and pitfalls. Hadron therapy: The clinical aspects. Tissue response models. Second cancers after radiotherapy.
Michael Joiner: Professor of Radiobiology, Wayne State University, USA
Albert van der Kogel: Emeritus Professor of Radiobiology, Radboud University Nijmegen Medical Centre, The Netherlands; also Department of Human Oncology, University of Wisconsin, USA
Date de parution : 08-2018
21x28 cm
Thèmes de Basic Clinical Radiobiology :
Mots-clés :
Tumour Control Probability; clinical application of radiobiology; Local Tumour Control; accreditation in radiation oncology; Spinal Cord; accreditation in clinical radiation physics; Dose Distribution; accreditation in radiation technology; Linear Quadratic Model; biological basis of radiation therapy; Proton Therapy; radiotherapeutic management of cancer; Single Dose Irradiation; mechanisms of cell death; Fractionated Irradiation; biological image guided radiotherapy; NTCP Model; molecular basis of radiation response; DNA Damage; tumour hypoxia; Concomitant Chemo Radiotherapy; radiotherapy for cancer treatment; Cell Survival Curves; cancers after radiotherapy; CSCs; Albert J; van der Kogel; Intensity Modulated Radiotherapy; G; Gordon Steel; High Dose Volume; Conchita Vens; Pet Imaging; Marianne Koritzinsky; Hypoxic Fraction; Bradly G; Wouters; Improve Local Tumour Control; Søren M; Bentzen; DNA Damage Response; Jay W; Burmeister; Clonogenic Cells; Wolfgang Dörr; Consequential Late Effects; Daniel Zips; Normal Tissue Damage; Michael Baumann; DVH; Mechthild Krause; Normal Tissue Stem Cells; Vincent Grégoire; Growth Factor Signalling; Robert P; Coppes; Richard P; Hill; Michael R; Horsman; J; Martin Brown; Jens Overgaard; Jean-Pascal Machiels; Catharine M.L; West; Robert G; Bristow; Adrian C; Begg; Karin Haustermans; John Lee; Dorota Gabryś; Fiona A; Stewart; Peter van Luijk; Klaus Rüdiger Trott