Part I. Introduction to the Host and Bacterial Pathogens: 1. Overview of the epithelial cell W. Vallen Graham and Jerrold R. Turner, 2. Evolution of bacterial pathogens Anthony Maurelli, Part II. Bacterial Cell Biology and Pathogenesis: 3. Bacterial secretion systems Helen J. Betts, Christopher M. Bailey, Mark J. Pallen and Ian Henderson, 4. Pathogen-associated molecular patterns and host detection Matam Vijay-Kumar and Andrew Gewirtz, 5. Flagella regulation and its secretion system Glenn Young, 6. The role of bacterial adhesion in bacterial pathogenesis Christof Hauck, 7. The role of bacterial toxins in bacterial pathogenesis Joseph Barbieri, Part III. Host Cell Signaling by Bacteria: 8. Host-mediated invasion Brit Winnen and Wolf-Detrich Hardt, 9. NF- kB dependent pathways Bobby Cherayil, 10. NF- kB independent pathways Beth A. McCormick and Randall J. Mrsny, Part IV. Exploitation of Host Niches by Pathogenic Bacteria: Mechanisms and Consequences: 11. Lung infections Marisa I. Gómez and Alice Prince, 12. Interactions of Helicobacter pylori with the gastric mucosa D. Scott Merrell, 13. Interactions of enteric bacteria with the intestinal mucosa Samuel Tesfay, Donnie Edward Shifflett and Gail Hecht, 14. Uropathogenic bacteria Luce Landraud, René Clément and Patrice Boquet.