Antibodies, Softcover reprint of the original 1st ed. 1987 Structure, Synthesis, Function, and Immunologic Intervention in Disease University of South Florida International Biomedical Symposia Series

This publication is based on a Symposium that has been held in Clearwater, Florida on February 19-21, 1986, on antibodies, their structure, synthesis, function, and clinical applicability in disease. Organization of this symposium by the University of South Florida College of Medicine was prompted by the unparalleled current expansion of information on these topics in general, and in the field of antibody diver­ sity, in particular. The issues that surround the last named dimension of this field, began to surface in the late 1950's with the first conclusive genetic studies having been answered, and a new set of concepts has been de­ fined. As we see it from the material presented in this volume, now new and different questions are being raised and answered by studies in progress, and it may be expected that there will be other questions that will be with us for a considerably longer time. We believe that the symposium brought together many prominent investi­ gators with different backgrounds and training experiences such as immunolo­ gists, microbiologists, biochemists, molecular biologists, and clinical sci­ entists, thus providing an excellent example of the interdisciplinary value of modern immunology and modern biomedical science in general. We believe, therefore, that bringing these complex topics to a wide audience of bio­ medical scientists through this symposium as well as this volume is of value to the scientific and to the medical community.

Section I. Structures of Antibodies and the Combining Site.- The Three Dimensional Structure of Immunoglobulin G and Its Relationship to the Expression of Biological Functions.- New Concepts in Antibody Structure.- Nature of the Antibody Combining Site.- Section II. B Cell Development, Function, Repertoire and Activation.- B Cell Development in Mammals.- Control of ? and ? Gene Expression in B Lymphocyte Development.- Functional Maturation of B Cell Repertoire Expression.- Receptor Cross-Linkage Stimulates B Cell Activation.- Section III. Antibody Idiotypes, Anti-Idiotypes, and Network Regulation.- Induction of Antibodies to Pseudorabies Virus by Immunization with Anti-Idiotypic Antibodies.- Network and Regulation of the Idiotypic Repertoire.- Anti-Hapten Idiotype Models in Studies of Aging and Idiotype Networks.- Section IV. Immunologic Intervention With Anti-Idiotype Antibodies.- Antibodies to Acetylcholine, Adenosine and Glucocorticoid Receptors by an Auto-Anti-Idiotypic Route.- Idiotypic Interactions in the Treatment of Human Diseases.- Regulation of Autoimmune Diseases.- Section V. Immunologic Intervention with Monoclonal Antibodies.- Transfectomas Provide Antibodies with Novel Structures and Functions.- The Use of Ricin A Chain-Containing Immunotoxins to Kill Neoplastic B Cells.- Monoclonal Antibodies and Immunoconjugates as Anti-Cancer Agents.- Section VI. Overview and Comments.- Overview and Comments.- Contributors.