Antibiotic Pharmacodynamics, 1st ed. 2016 Methods in Pharmacology and Toxicology Series

This text offers state of the art contributions written by world renown experts which provide an extensive background on specific classes of antibiotics and summarize our understanding as to how these antibiotics might be optimally used in a clinical situation.  The book explores pharmacodynamics methods for anti-infective agents, pharmacodynamics of antibacterial agents and non-antibacterial agents, as well as pharmacodynamic considerations and special populations. As part of the Methods in Pharmacology and Toxicology series, chapters include detailed insight and practical information for the lab.

1. General Concepts of Pharmacodynamics for Anti-Infective Agents

            Johan W. Mouton

2. In Vitro Pharmacodynamic Models to Evaluate Anti-Infective Pharmacodynamics

            Warren Rose

3. Animal Models to Evaluate Anti-Infective Pharmacodynamics

            Alexander J. Lepak and David R. Andes

4. Pharmacodynamic Issues in Antibiotic Combinations

            Zackery P. Bulman, Ryan C. Dillon, Sarith M. Saju, Neang S. Ly, Gauri G. Rao, Phillip J. Bergen, Cornelia B. Landersdorfer, Alan Forrest, Juergen B. Bulitta, and Brian T. Tsuji

5. Methodologies for Protein Binding Determination in Anti-Infective Agents

6. Evaluation of Exposure-Response Relationships Using Clinical Data: Basic Concepts and Applications<

            Sujata M. Bhavnani, Christopher M. Rubino, and Paul G. Ambrose

7. Toxicokinetics and Toxicodynamics of Anti-Infective Agents

            David E. Nix

Part II: Pharmacodynamics of Antibacterial Agents

8. Pharmacodynamics of Fluoroquinolones

            Ramy Elshaboury, Thomas Dilworth, and John Rotschafer

9. Aminoglycoside Pharmacodynamics

10. Polymyxin Phar

            Soon-Ee Cheah, Jian Li, Phillip J. Bergen, and Roger L. Nation

11. Vancomycin Pharmacodynamics: Optimal vs. Controversial

            Ben M. Lomaestro

12. Pharmacodynamics of Lipoglycopeptides

Eric Wenzler, Siyun Liao, and Keith A. Rodvold

<13. Pharmacodynamics of Daptomycin

            Eric Wenzler, Siyun Liao, and Keith A. Rodvold

14. Pharmacodynamics of Macrolides, Azalides, and Ketolides

            Wonhee So and David P. Nicolau

Part III: Pharmacodynamics of Non-Antibacterial Agents

15. Antifungal Pharmacokinetics and

            William Hope and David R. Andes

16. Pharmacokinetics and Pharmacodynamics of the Tuberculosis Drugs

            Aline B. Barth, Eric F. Egelund, and Charles A. Peloquin

17. Pharmacodynamics of Antimalarial Agents

            Rahul P. Bakshi and Theresa A. Shapiro

18. Pharmacodynamics of Antiviral Agents

            Renee-Claude Mercier, Bernadette Jakeman, and Larry Pineda

19. Pharmacodynamics of Antiretroviral Agents

            K

Part IV: Pharmacodynamic Considerations and Special Populations

20. Implementing a Continuous or Prolonged Infusion Be

            Shawn H. MacVane, Nathaniel J. Rhodes, Marc H. Scheetz, and Joseph L. Kuti

21. Pharmacodynamic Considerations in Critically Ill Patients

            Mahipal G. Sinnollareddy and Jason A. Roberts

22. Pharmacodynamic Considerations and Special Populations: Pediatrics

            Jennifer Le and John S. Bradley

23. Pharmacodynamics and Obesity

            Manjunath P. Pai

24. Drug Development Process and Regulatory Science

            Evelyn J. Ellis-Grosse and Jogarao Gobburu

25. Antibiotic Stewardship an

            Elizabeth D. Hermsen and Lynne Fehrenbacher

Forges a path toward new antibiotic development processes for licensing new antibiotics

Offers state-of-the-art contributions from world renowned experts

Explores how antibiotics might be optimally used in a clinical situation

Features practical, reproducible methods and key implementation advice