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Antibacterial Drug Discovery to Combat MDR, 1st ed. 2019 Natural Compounds, Nanotechnology and Novel Synthetic Sources

Langue : Anglais

Coordonnateurs : Ahmad Iqbal, Ahmad Shamim, Rumbaugh Kendra P.

Couverture de l’ouvrage Antibacterial Drug Discovery to Combat MDR

This book compiles the latest information in the field of antibacterial discovery, especially with regard to the looming threat of multi-drug resistance. The respective chapters highlight the discovery of new antibacterial and anti-infective compounds derived from microbes, plants, and other natural sources. The potential applications of nanotechnology to the fields of antibacterial discovery and drug delivery are also discussed, and one section of the book is dedicated to the use of computational tools and metagenomics in antibiotic drug discovery. Techniques for efficient drug delivery are also covered. The book provides a comprehensive overview of the progress made in both antibacterial discovery and delivery, making it a valuable resource for academic researchers, as well as those working in the pharmaceutical industry.



Section A: Problems associated with current antimicrobial therapy
1. Antibacterial drug discovery : perspective insights
2. Emergence and spread of multidrug resistance in ocular pathogens
3. Problematic groups of MDR bacteria and their resistance mechanisms
4. Biofilms in relation to enhanced drug resistance and persistence infection: challenges in chemotherapy
5. Environmental MDR a potential threat to human health and antimicrobial therapy
6. Impediments to discovery of new antimicrobials with new modes of action
7. Developing in vivo infection models with MDR pathogens for evaluating compound efficacy

Section B: New antibiotic drug discovery approaches and progress
8. Classical to improved microbial screening approaches for antibacterial drug discovery
9. Endophytes: a hidden treasure of novel antimicrobial metabolites
10. New molecular drug targets: potential for developing novel antibacterials against MDR bacteria
11. Bio-synthetic gene clusters associated with marine sponge and with bacterial dwelling in marine sponges
12. Insilico molecular modelling for drug screening
bioinformatics and chemoinformatics: key technologies in the drug discovery process
13. Computational Approaches in relation to antibacterial drug discovery
14. Efflux pump inhibitors and their role in reversal of drug resistance
15. Medicinal plants as reservoir of new structure for anti-infective compounds
16. Antibacterial essential oils: Potential application in bacterial disease management.
17. Metagenomic approach to explore soil resistome.
18. Marinemicrobes as promising source of new leads as antibacterials: Current progress and prospects

Section C:Alternative antibiotic resistance treatment strategy
19. Role of pre and probiotics in protection from pathogenic bacteria
20. Enhancing antibiotic efficacy through synergistic approach
21. Reviving old antibiotics
22. Targeted Delivery of antibiotics using polymeric particles to combat TB resistance
23. Bacteriophages in pathogenic bacterial control: prospects and limitation.
24. Inhibition of Quorum sensing; prospects in disease control
25. Pathogenic Biofilm eradication strategies in combating bacterial infection

Section D:Nanomaterials as antibacterial drug: potentials and prospects
26. Nanomedicine /Nanoemulsion in increasing drug availability
27. Nanoparticle as new emerging antibacterials: potential and limitation
28. Antibiofilm and antivirulence action of nanopartciles
29. Nanoparticle-based drug delivery systems: promising approaches against bacterial infections
30. Green synthesis of metal nanoparticles: characterization and their antibacterial efficacy
31. Protein and Peptide Nanoparticles for antibacterial Drug Delivery

Professor Iqbal Ahmad

Iqbal Ahmad is a Full Professor and former Chair of the Department of Agricultural Microbiology, Aligarh Muslim University, Aligarh, India.  He is also the Coordinator, Faculty of Agricultural Sciences, AMU for the BSc (Hons) Agriculture course.  He has extensive teaching and research experience in applied & interdisciplinary microbiology and medicinal plant-derived natural products. His present research interest is in the field of AMR in pathogenic bacteria of environmental and clinical origin and conducting research on interference of quorum sensing-linked virulence factors and biofilms by natural products including medicinal plants as a possible alternative strategy to combat MDR. Dr. Ahmad has published more than 150 original research papers, 10 edited books, and 50 book chapters. In addition, he serves as an active reviewer/member of the editorial board for many prominent research journals. 

Prof (Dr.) Kendra P. Rumbaugh

Kendra Rumbaugh is a Professor at the Department of Surgery, with joint appointments at the Departments of Immunology and Molecular Microbiology and Cell Biology and Biochemistry at Texas Tech University Health Sciences Center in Lubbock, Texas. Dr. Rumbaugh’s research focuses on understanding and treating wound infections, and she is especially interested in how biofilms, polymicrobial interactions and quorum sensing contribute to bacterial pathogenesis. She has edited books on quorum sensing (Springer) and antibiofilm agents (Springer), and serves on many international science advisory boards, program committees and the editorial boards of many high ranked journals.

 

Prof (Dr.) Shamim Ahmad

Shamim Ahmad is a senior Professor of Ocular Microbiology at the Institute of Ophthalmology, JN Medical College, Faculty of Medicine, Aligarh Muslim University, Aligarh, India. He has also served as faculty on deputation from AMU Aligarh a

Gives a holistic overview of efforts made by various research disciplines to combat the MDR problem through natural products

Introduces new dimensions in antibacterial drug discovery and alternative modes of combating bacterial infections

Suggests ways for minimizing the emergence and spread of MDR pathogens

Date de parution :

Ouvrage de 680 p.

15.5x23.5 cm

Disponible chez l'éditeur (délai d'approvisionnement : 15 jours).

Prix indicatif 210,99 €

Ajouter au panier

Date de parution :

Ouvrage de 680 p.

15.5x23.5 cm

Disponible chez l'éditeur (délai d'approvisionnement : 15 jours).

Prix indicatif 210,99 €

Ajouter au panier