Alzheimer's Disease: Cellular and Molecular Aspects of Amyloid beta, 2005 Subcellular Biochemistry Series, Vol. 38

To understand Alzheimer's disease (AD) is one of the major thrusts of present-day clinical research, strongly supported by more fimdamental cellular, biochemical, immunological and structural studies. It is these latter that receive attention within this book. This compilation of 20 chapters indicates the diversity of work currently in progress and summarizes the current state of knowledge. Experienced authors who are scientifically active in their fields of study have been selected as contributors to this book, in an attempt to present a reasonably complete survey of the field. Inevitably, some exciting topics for one reason or another have not been included, for which we can only apologize. Standardization of terminology is often a problem in science, not least in the Alzheimer field; editorial effort has been made to achieve standardization between the Chapters, but some minor yet acceptable personal / author variation is still present, i. e. P-amyloid/amyloid-P; Ap42/Apl-42/APi. 42! The book commences with a broad survey of the contribution that the range of available microscopical techniques has made to the study of Alzheimer's amyloid plaques and amyloid fibrillogenesis. This chapter also serves as an Introduction to the book, since several of the topics introduced here are expanded upon in later chapters. Also, it is significant to the presence of this chapter that the initial discovery of brain plaques, by Alois Alzheimer, utilized light microscopy, a technique that continues to be extremely valuable in present-day AD research.

The Contribution of Microscopy to the Study of Alzheimer’s Disease, Amyloid Plaques and A? Fibrillogenesis.- Transgenic Mouse Models for APP Processing and Alzheimer’s Disease: Early and Late Defects.- Oxidative stress in Alzheimer’s Disease: Implications for Prevention and Therapy.- ?-Secretase, APP and A? in Alzheimer’s Disease.- The Non-Amyloidogenic Pathway: Structure and Function of ?-Secretases.- Amyloid ? Degradation: A Challenging Task for Brain Peptidases.- The Protective Role of Vitamin E in Vascular Amyloid ?-Mediated Damage.- Amyloid Accumulation and Pathogensis of Alzheimer’s Disease: Significance of Monomeric, Oligomeric and Fibrillar A?.- Cholesterol and Amyloid ? Fibrillogenesis.- Alzheimer’s ?-Amyloid: Insights into Fibril Formation and Structure from Congo Red Binding.- The Aluminium-Amyloid Cascade Hypothesis and Alzheimer’s Disease.- Amyloid-? Metal Interaction and Metal Chelation.- The Interaction of Amyloid-? with ApoE.- Clusterin and Alzheimer’s Disease.- Acetylcholinesterase Interaction with Alzheimer Amyloid ?.- Membrane Disordering Effects of ?-Amyloid Peptides.- The Role of Alzheimer A? Peptides in Ion Transport Across Cell Membranes.- Amyloid Inhibitors and ?-Sheet Breakers.- Cholesterol and Alzheimer’s Disease: Statins, Cholesterol Depletion in APP Processing and A? Generation.- Phosphorylated Amyloid-?: the Toxic Intermediate in Alzheimer’s Disease Neurodegeneration.

The diversity of the up-to-date highly relevant biomedical material included The exciting presentation of the material throughout, with numerous photo micrographs, charts, tablular and diagrammatic illustrations The emphasis upon the broad contribution of microscopial techniques to the study of Alzeimer’s disease The emphasis upon the value of transgenic animal models for the study of Alzheimer’s disease The emphasis on the role of cholesterol in Alzheimer’s disease