Ageing: Lessons from C. elegans, 1st ed. 2017 Healthy Ageing and Longevity Series, Vol. 5
Coordonnateurs : Olsen Anders, Gill Matthew S.
This book brings together in one volume the current state of ageing research in the nematode Caenorhabditis elegans. The authors are leading researchers in the field, placing this topic in the context of human ageing, describing how and why basic discoveries in this simple organism have impacted our prospects for intervention in the ageing process. The authors cover a broad range of topics with regards to organismal and reproductive ageing including anatomical, physiological and biochemical changes, as well as genetic and environmental interventions that promote longevity and ameliorate age-related disease. Ageing is the single most important factor determining the onset of human disease in developed countries. With current worldwide demographic trends indicating that the number of individuals over the age of 65 will continue to rise, it is clear that an understanding of the processes that underpin ageing and age-related disease represents a key challenge in the biomedical sciences. In recent years there have been huge advances in our understanding of the ageing process and many of these have stemmed from genetic analysis of C. elegans.
With no analogous book in this subject area this work will be of interest to a wide audience, ranging from academic researchers to the general public.
Chapter 1
Introduction - Anders Olsen and Matthew S. Gill
Chapter 2
Effects of aging on the basic biology and anatomy of C. elegans - Laura A. Herndon, Catherine A. Wolkow, Monica Driscoll and David H. Hall
Chapter 3
Dauer Formation and Ageing - Pedro Reis Rodrigues, Kailiang Jia and Matthew S. Gill
Chapter 4
Longevity regulation by insulin/IGF-1 signaling - Seon Woo A. An, Murat Artan, Sangsoon Park, Ozlem Altintas, and Seung-Jae V. Lee
Chapter 5
Mitochondrial longevity pathways - Alfonso Schiavi and Natascia Ventura
Chapter 6
Influences of Germline Cells on Organismal Lifespan and Healthspan - Francis R.G. Amrit and Arjumand Ghazi
Chapter 7
Reproductive Aging - Cheng Shi & Coleen T. Murphy
Chapter 8
Nervous System Ageing - Claire Bénard and Maria Doitsidou
Chapter 9
Stress Response Pathways - Dana L. Miller*, Joseph Horsman, and Frazer Heinis
Oxidative Stress - Bart P. Braeckman, Patricia Back, Filip Matthijssens
Chapter 11
Genome stability and ageing - Aditi U. Gurkar, Matthew S. Gill and Laura J. Niedernhofer
Chapter 12
Protein homeostasis and ageing in C. elegans - Silvestre Alavez
Chapter 13
Translational control of longevity - Jarod Rollins and Aric Rogers
Chapter 14
Lipid Metabolism, Lipid Signaling and Longevity - Jonathon Duffy, Ayse Sena Mutlu, Meng C. Wang
Chapter 15
Autophagy and ageing - Malene Hansen
Chapter 16
Dietary restriction in C. elegans - Yue Zhang and William B. Mair
Chapter 17
Integration of metabolic signals - Dana A. Lynn and Sean P. Curran
Chapter 18
Microbiota, Probiotic Bacteria and Ageing - Katrine V. Christensen, Maria G. Morch, Tine H. Morthorst, Simon Lykkemark and Anders Olsen
Chapter 19
The Future of Worm Ageing - Gordon J. Lithgow
Index
Provides a complete overview of the current state of ageing research in C. Elegans
Offers a unique focus on relevance for human ageing
Written by world’s leading researchers in the field of C. elegans ageing
Date de parution : 12-2016
Ouvrage de 439 p.
15.5x23.5 cm
Date de parution : 07-2018
Ouvrage de 439 p.
15.5x23.5 cm
Thème d’Ageing: Lessons from C. elegans :
Mots-clés :
Ageing; Caenorhabditis elegans; Healthspan; Life extension; Longevity-associated genes
