Advances in Chromatography, Volume 49

Advances in Chromatography is a venerable series that has reported on the latest state-of-the-art developments in the field for the past four decades. The newest installment, Volume 49, continues the tradition of compiling the work of expert contributors who present timely and cutting edge reviews of current and emerging methods and applications in this dynamic field.

Highlights in this edition include:

• The hyphenation of liquid chromatography with mass spectrometry in order to determine oligonucleotide adducts as markers for cancer



• Glycoproteomics and the glycosylation of proteins, addressing biomarkers in different types of diseases



• Chiral separation, an important area particularly in the pharmaceutical industry, where the technique has been applied with varying results



• Ion-pairing chromatography and analyte retention

Conveying the most recent significant scientific developments in separation science, the book and its series are known for the authors? clear presentation of topics and vivid illustrations. Accessible and engaging, this volume forms a solid foundation for the work of biochemists and analytical, organic, polymer, and pharmaceutical chemists at all levels of technical skill. Meticulously referenced, it will help fuel further research across a range of fields.

Retention Mechanism for Ion-Pair Chromatography with Chaotropic Reagents: From Ion-Pair Chromatography toward a Unified Salt Chromatography. Mechanistic Aspects of Chiral Recognition on Protein-Based Stationary Phases. Mechanistic Aspects and Applications of Chiral Ligand-Exchange Chromatography. Glycosylation Analysis of Proteins, Proteoglycans, and Glycolipids Using Capillary Electrophoresis and Mass Spectrometry. Oligonucleotide Adducts as Biomarkers for DNA Damages: Analysis by Mass Spectrometry Coupled to Separation Methods. Quantitative In Silico Analysis of the Specificity of Graphitized (Graphitic) Carbons. Application of Column-Switching Methods in HPLC for Evaluating Pharmacokinetic Parameters. Chromatographic Procedures in a Regulated Environment. The Use of Novel Materials as Solid-Phase Extractors for Chromatographic Analysis. Thin-Layer and High-Performance Thin Layer Chromatographic Analysis of Biological Samples. Index.

Eli Grushka is currently with Hebrew University of Israel, Jerusalem. Nelu Grinberg is with Boehringer-Ingelheim Pharmaceuticals of Ridgefield, Connecticut.