Advances in Cancer Research Advances in Cancer Research Series
Directeurs de Collection : Tew Kenneth D., Fisher Paul
2. Bioengineering Strategies for Cancer Targeting
3. Advances in Understanding the Coupling of DNA Base Modifying Base Enzymes to Processes Involving Base Excision Repair
4. Recent Advances in the Treament of Prostrate Cancer Stemming from Improvements in the Biology of the Disease
5. Autophagy: Cancer's Friend or Foe
The Tew laboratory maintains an interest in using redox pathways as a platform to develop therapeutic strategies through drug discovery/development and biomarker identification. We interrogate how reactive oxygen and nitrogen species (ROS/RNS) impact cancer cells and develop novel drugs that impact on glutathione based pathways. Our research efforts have been integral to studies that have identified glutathione S-transferases (GST) as important in drug resistance, catalytic detoxification and as arbiters of kinase-mediated cell signaling events. In addition, we have been instrumental in defining how GSTP contributes to the process by which cells respond to ROS by selective addition of glutathione to specific protein clusters, so called S-glutathionylation. Each of these research areas has had broad impact on a number of cancer disciplines. Moreover, we have also been seminally involved in the Phase I to III clinical testing of three oncology drugs, Telcyta, Telintra and NOV-002. Other ongoing translational efforts have produced two ongoing clinical trials to measure the effectiveness of serum S-glutathionylated serine proteinase inhibitors as possible biomarkers for exposure to hydrogen peroxide mouthwashes and radiation.
- Provides information on cancer research
- Oustanding and original reviews
- Suitable for researchers and students
Date de parution : 07-2013
Ouvrage de 416 p.
15x22.8 cm
