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Molecular Nutrition: Fats An Analysis of Implications on Cells to Public Health

Langue : Anglais

Coordonnateur : Patel Vinood B.

Couverture de l’ouvrage Molecular Nutrition: Fats

Molecular Nutrition: Fats presents the nutritional and molecular aspects of fats by assessing their dietary components, their structural and metabolic effects on the cell, and their role in health and disease. Subject areas include molecular mechanisms, membranes, polymorphisms, SNPs, genomic wide analysis, genotypes, gene expression, genetic modifications and other aspects. The book is divided into three sections, providing information on the general and introductory aspects, the molecular biology of the cell, and the genetic machinery and its function. Topics discussed include lipid-related molecules, dietary lipids and lipid metabolism, high fat diets, choline, cholesterol, membranes, trans-and saturated fatty acids, and lipid rafts.

Other sections provide comprehensive discussions on G protein-coupled receptors, micro RNA, transcriptomics, transcriptional factors, cholesterol, triacylglycerols, beta-oxidation, cholesteryl ester transfer, beta-oxidation, lysosomes, lipid droplets, insulin mTOR signaling and ligands, and more.



  • Summarizes molecular nutrition in health as related to fats
  • Discusses the impact of fats on cancer, heart disease, dementia, and respiratory and intestinal disease
  • Includes preclinical, clinical and population studies
  • Covers the genome, the whole body and whole communities
  • Includes key facts, a mini dictionary of terms and summary points

Part 1: General and Introductory Aspects 1. Nomenclature, classes and functions of lipids and lipid-related molecules 2. Dietary lipids and lipid metabolism: an overview 3. Essential fatty acid deficiency in humankind 4. High fat diets, choline and cholesterol metabolism 5. Lipid membranes 6. Trans and saturated fatty acid levels in the blood and impact of diet 7. Fat-soluble vitamins and importance in the diet 8. Lipid emulsions in artificial nutrition 9. Fatty acid intake and cancer risk 10. Monounsaturated fatty acids and cancer 11. Combining omega-3 fatty acids and long-chain monounsaturated fatty acids in diets and effects in health 12. Lipid peroxidation and impact of products on 13. Sterols, stanols and statins 14. Hepatic steatosis 15. Lipids in emulsions 16. Omega-3 supplements and cardiovascular disease 17. Trans-fatty acids and coronary heart disease 18. Lipds and dementia 19. Intestinal disease and bioactive lipids 20. Respiratory disease and dietary lipids 21. Long chain polyunsaturated fatty acids in pregnancy 22. Lipid-based nutrient supplements to children 23. Lactation and dietary lipids 24. Public health aspects of nutritional counseling and low-density lipoprotein cholesterol 25. Public health impact of fatty acid intake and depression 26. Lipids in the diet and capillary dysfunction: public health implications of Alzheimer’s disease 27. C-reactive protein and plasma fatty acids: public health concerns and implications

Part 2: Molecular Biology of the Cell 28. The mitochondria as a site of fatty acid beta-oxidation 29. Subcellular organelles: lysosomes in lipid accumulation 30. Subcellular organelles: lipid droplets 31. Lipid raft formation in macrophages 32. Lipid rafts in vascular endothelial cells 33. G protein-coupled receptor 120 (GPR120) 34. The Bile Sale Export Bump (BSEP) and lipid metabolism 35. Dietary fat and insulin: from cell exposure to transcriptional processes 36. Stearoyl-CoA desaturase indexes as biomarkers in cardiometabolic 37. Polyunsaturated fatty acids and mTOR signaling Prof. P.A. Marignani 38. N-6 polyunsaturated fatty acids and brain polyunsaturated fatty acids 39. Fatty acid amide ligands and G protein-coupled receptors 40. Dietary fatty acids and weight gain via receptor activation: a focus on the endocannabinoid system 41. Lipid composition and intracellular trafficking 42. The LXR/SREBP-1c signaling pathway, lipids and atherosclerosis 43. Heart tissue, lipids and PKC activation 44. Brain signaling and monounsaturated dietary lipids compared to polunsaturated

Part 3: Genetic Machinery and Its Function 45. Intracerebral hemorrhages and genetic loci for serum total, LDL, and HDL cholesterol, and triglycerides 46. DNA methylation patterns and n-3 fatty acid intake 47. Glucokinase gene variations and fish oil 48. Dietary free fatty acids and gene expression in adipocytes and other cell types 49. Alternative splicing and cholesterol 50. Polymorphisms in triacylglycerol metabolism 51. Fatty acids and desaturase gene polymorphism in elderly 52. Polymorphisms of the CETP gene and public health implications 53. Fatty acid binding protein 2 genes and public health implications for diabetes 54. Polymorphisms in fatty acid beta-oxidation 55. Cholesteryl ester transfer protein polymorphisms 56. Micro RNA (miRNA) and lipid metabolism 57. Transcriptomics and n-3 polyunsaturated fatty acids supplementation 58. Transcriptional factor modulation by lipid peroxidation-derived aldehydes

Researchers, professionals (including nutritionists, dieticians, health scientists, health care professionals, policy makers), educators, and students

Vinood B. Patel, BSc, PhD, FRSC, is currently a Reader in Clinical Biochemistry at the University of Westminster and honorary fellow at King’s College London (Diabetes and Nutritional Sciences Division and the Department of Nutrition and Dietetics). He presently directs studies on molecular and metabolic pathways involved in organ disease, particularly related to subcellular organelles and cell death. He directs research into the role of nutrients, antioxidants, phytochemicals, minerals, toxins and macronutrients. Other areas of interest are identifying new biomarkers that can be used for the diagnosis and prognosis of disease and understanding oxidative stress. Dr Patel graduated from the University of Portsmouth with a degree in Pharmacology and completed his PhD in protein metabolism from King’s College London in 1997. His postdoctoral work was carried out at Wake Forest University Baptist Medical School studying structural-functional alterations to mitochondrial ribosomes, where he developed novel techniques to characterize their biophysical properties. Dr Patel is a nationally and internationally recognized liver researcher and was involved in several NIH-funded biomedical grants. Dr Patel has edited more than 20 biomedical books in the area of nutrition, health and disease and has published over 150 articles In 2014, he was elected as a Fellow to the prestigious Royal Society of Chemistry for bridging the academic and intellectual gap between chemistry and biological function.

Date de parution :

Ouvrage de 1072 p.

21.6x27.6 cm

Disponible chez l'éditeur (délai d'approvisionnement : 14 jours).

Prix indicatif 193,44 €

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