Methods in bioengineering: Alternative technologies to animal testing (Methods in bioengineering series) Series

Written and edited by recognized experts in the field, the new Artech House Methods in Bioengineering book series offers detailed guidance on authoritative methods for addressing specific bioengineering challenges. Offering a highly practical presentation of each topic, each book provides research engineers, scientists, and students with step-by-step procedures, clear examples, and effective ways to overcome problems that may be encountered. Providing alternatives to animal testing is one of the hottest topics in biomedical research, and this groundbreaking volume addresses this critical issues head on. This unique book presents techniques and methods at the forefront of scientific research that have the potential to replace certain whole animal tests. Moreover, this book provides a platform where other widely accepted techniques and scientific advancements can be collated into a concise set of methods that can be implemented within both academic and industrial communities.

Current Methods for Prediction of Human Hepatic Clearance Using In Vitro Intrinsic Clearance. Use of Permeability from Cultured Cell Lines and PAMPA system, and Absorption from Experimental Animals for the Prediction of Absorption in Humans. Aggregating Brain Cell Cultures for Neurotoxicity Tests. Approaches Towards a Multi-Scale Model of Systemic Inflammation in Humans. A Liposome Assay for Evaluating the Ocular Toxicity of Chemicals. Prediction of Potential Drug Myelotoxicity by In Vitro Assays on Haematopoietic Progenitors. Epigenetically Stabilized Primary Hepatocyte Cultures: A Potential Sensitive Screening Tool for Non-Genotoxic Carcinogenicity. A Statistical Method to Reduce In Vivo Product Testing Using Related In Vitro Tests and ROC Analysis. Application of the Benchmark Apporach in the Correlation of In Vitro and In Vivo Data in Developmental Toxicity. Three-Dimensional Cell Culture of Canine Uterine Glands. Markers for an In Vitro Skin Substitute. 3D Culture of Primary Chonrocytes, Cartilage, and Bone/Cartilage Explants in Simulated Microgravity. Alternatives for Absorption Testing. A 3D Model of the Human Epithelial Airway Barrier. Experimental Wear Assessment of Tibial Inserts for Total Knee Replacement.