Plant bioactives and drug discovery: Principles, practice, and perspectives

Highlighting the complexity and applications of plant bioactive metabolites in organic and medicinal chemistry, this book overviews plant biodiversity as a source of new drugs and drug discovery strategies. In addition, the book describes the role of natural products as drugs targeting specific disease areas, including neurological disorders, inflammation, infectious diseases, and cancer. The coverage also discusses natural products in clinical trials, quality control, and case studies of medicinal plants. A complete sourcebook for this topic, the text includes chapters on marketing, regulations, intellectual property, and academic-industry collaboration.

Chapter 1. Natural products in drug discovery: recents advances
Gordon M. Cragg, Paul G. Grothaus, David J. Newman

Chapter 2. Modern approaches in the search for new active compounds from crude extracts of natural sources
Emerson F. Queiroz, Kurt Hostettmann, Jean-Luc Wolfender

Chapter 3. Natural product as lead compounds in medicinal chemistry
Eliezer J. Barreiro, Carlos A. M. Fraga, Lidia M. Lima

Chapter 4. The importance of structural manipulation of natural compounds in drug discovery and development
Arturo San Feiliciano, Maria Á. Castro, José L. López-Pérez and Esther del Olmo

Chapter 5. The action of plants and their constituents on the central nervous system
Fúlvio R. Mendes, Gina Negri, Joaquim M. Duarte-Almedia, Ricardo Tabach, Elisaldo A. Carlini

Chapter 6. The role of natural products in discovery of new anti-infective agents with emphasis on antifungal compounds
Maximiliano Sortino, Marcos Derita, Laura Svetaz, Marcela Raimondi, Melina Di Liberto, Elisa Petenatti, Mahabir Gupta, Sisana Zacchino

Chapter 7. Antiulcer agent from higher plants
Luiz C. Klein-Júnior, José R. Santin, Sérgio F. de Andrade

Chapter 8. Recent progress in the chemistry and biology of pacilitaxel (Taxol) and related taxanes
Jun Qi, Jielu Zhao, David G. I. Kingston

Chapter 9. Cancer chemopreventive activity of higher plants
A.Douglas Kinghorn, Yulin Ren, Jie Li, Chung Ki Sung

Chapter 10. Medicinal plants and pharmaceutical technology
Ruth M. Lucinda da Silva, Angélica G. Couto, Tania M. B. Bresolin

Chapter 11. Natural products in clinical trails
Sigrun Chrubasik

Chapter 12. The influence of biotic and abiotic factors on the production on secondary metabolites in medicinal plants
Dayana R. Gouveia, Leonardo Gobbo-Neto, Norberto P. Lopes

Chapter 13. Production of bioactives compounds: the importance of Pictet-Spengler reaction in the XXI Century
Pilar Menendez, Ilaria D'Acquarica, Giuliano Delle Monache, Francesca Ghirga, Andrea Calcaterra, Marco Barba, Alberto Macone, Alberto Boffi, Alessandra Boramore, Bruno Botta

Chapter 14. Screening methods for drug discovery from plants
Alan L. Harvey

Chapter 15. Phytotherapeutics - intellectual property rights, global market, and global regulatory guidelines
James D. McChesney, Raymond Cooper, Kip Vought

Chapter 16. Cooperation between the pharmaceutical industry and academic instiutions in drug discovery
Valdir Cechinel Filho, Rivaldo Niero and Rosendo A. Yunes