Biotechnology & Genetic Engineering Reviews Vol. 23

Advances in high-throughput methodologies for crystallizing proteins. LC-MS-based protein and peptide quantification using stable isotope labels: from ICAT in general to differential N-terminal coding (dNIC) in particular. Crosslinking strategies for the study of membrane protein complexes and protein interaction interfaces. History and current status of nuclear transfer cloning. Promoting gene therapy: expression systems for transgenes and post-transcriptional gene silencing. Genome-wide mapping of histone modifications by GMAT. Signalling through chromatin modifications and protein-protein interactions. Insect transgenesis: mechanisms, applications and ecological safety. Analysing the metabolic capabilities of Desulfo-vibrio species through genetic manipulation. Endophytic bacteria and their potential application to improve the phytoremediation of contaminated environments. Transformation-induced mutations in transgenic plants: analysis and biosafety implications. Self-processing polyproteins: a strategy for co-expression of multiple proteins in plants. Plantibodies: a novel strategy to create pathogen-resistant plants. Mechanisms controlling self-renewal and pluripotency in human embryonic stem cells. Adipose-derived mesenchymal cells (AMCS): a promising future for skeletal tissue engineering. Dendrimer-based drugs as macromolecular medicines. Patenting applied to genetic sequence information. Index.