Immunotherapy of Cancer, (Cancer drug di scovery & development)

This book provides a general background as well as an overview and update of the use of cancer immunotherapy. Aside from highlighting new advances and directions in cancer immunotherapy, also covered are the most common forms of cancer immunotherapy, challenges in clinical trial design and the need for biomarkers of response.

Discovery of Target Molecules for Cancer Immunotherapy by Genetic and Bioinformatic ApproachesÖzlem Türec. Thorsten Klam. Michael Koslowsk. Sebastian Kreite. and Ugur SahinCurrent Strategies for the Identification of Immunogenic Epitopes of Tumor AntigensLudmila Mülle. Stephanie McArdl. Evelyna Derhovanessia. Thomas Fla. Ashley Knight. Robert Ree. and Graham PawelecCurrent and Future Role of Natural-Killer Cells in Cancer ImmunotherapyLisa M. Harlan and Julie Y. DjeuThe Role of Immune Monitoring in Evaluating Cancer ImmunotherapyHolden T. MaeckerStatistical Analysis of Immune Response Assays in Cancer Immunotherapy TrialsSusan GroshenDNA Vaccines for Cancer ImmunotherapyHeesun Kwak and Howard L. KaufmanDendritic CellsWeiping Zou and Tyler J. CurielDifferent Approaches to Dendritic Cell-Based Cancer ImmunotherapyNoweeda Mirza and Dmitry GabrilovichAnti-Idiotype Antibody Vaccines for the Immunotherapy of CancerMalaya Bhattacharya-Chatterje. Nitin Rohatg. Sunil K. Chatterje. Asim Sah. Rakesh Shukl. and Kenneth A. FoonAutologous Tumor-Derived Heat Shock Protein Vaccine as a New Paradigm for Individualized Cancer TherapeuticsJie Dai and Zihai LiTumor-Reactive T-Cells for Adoptive ImmunotherapyHelga Bernhar. Julia Neudorfe. Kerstin Gebhar. Heinke Conra. Dirk H. Busc. and Christian PeschelT-Cell Adoptive Immunotherapy of Cancer: From Translational Models to Clinical SignificancePeter A. Cohe. Mohamed Awa. and Suyu ShuRetroviral-Mediated Gene Transfer for Engineering Tumor-Reactive T-CellsJeffrey J. Roszkowski and Michael I. NishimuraHarnessing the Potential of Graft-vs-TumorNancy M. Hardy and Michael R. BishopTumor-Induced Immune Suppression and Immune Escape: Mechanisms and Impact on the Outcome of Immunotherapy of Malignant DiseaseMichael Campoli and Soldano FerroneThe Tumor Microenvironment: Regulation of Antitumor Immunity and Implications for ImmunotherapyGeorge Coukos and Jose-Ramon Conejo-GarciaManipulation of Lymphocyte Homeostasis for Enhancing Antitumor ImmunityEduardo Davila and Esteban CelisFast-Lane Evolution in the Tumor MicroenvironmentGabriella Marincola and Francesco M. MarincolaManipulating Immunological Checkpoints to Maximize Antitumor ImmunityLeisha A. Emen. R. Todd Reill. and Elizabeth M. JaffeeInterleukin-2 as Cancer TherapyJoseph I. Clark and Kim A. MargolinBiological and Clinical Properties of the Type 1 InterferonsDouglas W. Leama. Shaun Rosebec. and Ernest C. BordenPromising g-Chain Cytokines for Cancer Immunotherapy: Interleukins-. -1. and -21 as Vaccine Adjuvant. Growth Factors and ImmunorestorativesTerry J. Fry and Crystal L. MackallThe Therapeutic Use of Natural-Killer Cells in Hematological MalignanciesSherif S. Farag and Michael A. CaligiuriAntibody Therapy for Solid TumorsCristina I. Truic. Dorinda Rouc. and Carlos L. ArteagaAntibody Therapy for Non-Hodgkin's LymphomaStephen M. Ansell and Thomas E. WitzigApproaches to In Vivo Imaging of Cancer ImmunotherapyGeorge A. Vielhaue. Bond Alman. Mary L. Disi. David A. Mankof. and Keith L. KnutsonDesign Issues for Early-Stage Clinical Trials for Cancer VaccinesGina R. PetroniMonoclonal Antibody Therapy of CancerHossein Borghae. Matthew K. Robinso. and Louis M. WeinerIndex