Particle and surface characterisation methods

This book is based on lectures presented at the colloidal drug carriers meeting, held in Mainz, Germany, March 6, 1997. A full range of different characterization methods is presented. It contains information about the basic theory, possibilities but also limitations in resolution and application of the various methods. It includes measurement of particle size using laser light scattering techniques, the PIDS technology. The validation of software and hardware is considered. Determination of surface area is described, focusing on modern BET instruments.

The characterisation of surfaces is an important tool for quality control and for understanding the interactions of surfaces with their environments. In this book, a full range of different characterization methods is presented. It provides an overview that allows readers to identify the best method for particular analytical problems. The chapters contain information on basic theory and possibilities and limitations in resolution and application of each method.
The methods discussed include measurement of particle size using laser light scattering techniques. The book also presents the latest development in the field-Polarization Intensity Differential Scattering (PIDS) technology. Other techniques such as two-dimensional PAGE and circular dichroism are addressed as well.
Particle and Surface Characterisation Methods offers a thorough examination of analytical methods and instruments for those working in a variety of fields from pharmaceutical development to polymer chemistry and development of medicinal devices. Readers will discover the most efficient and suitable methods for a variety of applications with this valuable reference.

Multiangle Photon Correlation Spectroscopy in Particle Characterisation. Possibilities and Limitations of Laser Light Scattering Techniques for Particle Size Analysis. Improvements in Particle Size Analysis Using Light Scattering. Particle Sizing in the Sub-Micron Range by Laser Diffraction. A Guide to the Validation of Laser Diffraction-Based Particle Size Analysers. Confocal Laser Scanning Microscopy and its Application in Liposomal Research. Introduction to Atomic Force Microscopy and Its Application to the Study of Lipid Nanoparticles. FTIR Techniques for Surface Characterisation. Circular Dichroism (CD) for the Analysis of Dissolved and Adsorbed Proteins. The Surface Structure of Lipid Drug Carriers--Influence on Carrier-Cell Interaction. Surface Area Analysis of Finely Divided and Porous Solids by Gas Adsorption Measurements. Determination of Surface Area in Comparison. The Surface Area of Magnesium Stearate: An Example for a Complex Analysis Task. Surface Hydrophobicity-Determination by Rose Bengal (RB) Adsorption Methods. Theory and Set Up of Hydrophobic Interaction Chromatography (HIC. Hydrophobic Interaction Chromatography (HIC) for Determination of the Surface Hydrophobicity of Particulates. HIC of Iron Oxide Dispersions Stabilized by Different Macromolecules. Two-Dimensional Polyacrlamide Gel Electrophoresis (2-D Page) for the Analysis of Protein Adsorption onto Surfaces. Index.


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