Therapeutic Applications of Adenoviruses Gene and Cell Therapy Series

Adenoviruses are double stranded DNA viruses that have been used to study the process of DNA replication. Studies of the mode of action of adenovirally produced tumors in rodents led to the discovery of tumour supressor genes. The adenoviral vector is now the most used vector in clinical gene therapy especially for some kinds of cancers. The chapters in this book focus on the most up-to-date developments in the therapeutic applications of adenoviruses. The intended audience is individuals in the Life Sciences interested in therapeutic applications of adenoviruses. This book reviews the life history and immune responses to adenoviruses and summarizes various therapies implemented with the use of adenoviruses.

Adenovirus Biology: Virus structure and life cycle. Immune responses to adenovirus. Helper-dependent adenoviral vectors for gene and cell therapy. Genetic and capsid modified Adenovirus. Adenovirus for vaccination. FGAd and HDAd. Adenovirus vectors for cancer therapy. Adenovirus-based hybrid vectors. FDA expectations and requirements of adenoviral products.

Philip Ng is jointly an Associate Professor of Department of Molecular and Human Genetics and the Program in Translational Biology & Molecular Medicine at the Baylor College of Medicine. He is interested in developing gene therapies for genetic diseases using helper-dependent adenoviral vectors (HDAd).

Nicola Brunett-Pieri is an Associate Professor in the Department of Translational Medicine at Federico II University in Naples and an Associate Investigator at Telethon Institute of Genetics and Medicine (TIGEM).