Recurrent Pregnancy Loss (3^rd Ed.)

This new edition is a comprehensive guide to recurrent pregnancy loss for practising gynaecologists.

Divided into ten sections, the book begins with a brief overview of the topic, followed by discussion on the different causes of pregnancy loss ? genetic, endometrial, systemic, anatomical and infections. The next sections discuss management options, the role of ultrasound, and failed pregnancy.

The third edition has been fully revised and expanded to bring clinicians fully up to date with the latest advances in the field.

Newer treatment options are covered in depth and the latest diagnostic recommendations from the RCOG (UK) as well as the ACOG (US) are included.

Authored by a team of internationally recognised experts, the text is enhanced by clinical photographs and diagrams, and features a comprehensive appendix section for further reference.

Key points

• Fully revised, third edition presenting latest knowledge in recurrent pregnancy loss
• Covers newer treatment options and latest diagnostic recommendations from RCOG and ACOG
• Authored by internationally recognised team of experts
• Previous edition (9788184480061) published in 2007

Section 1: Introduction

• Overview & Terminology Clarified
• Cytokines and The Success/Failure of Pregnancy

Section 2: Genetic Causes

• Overview of Genetic Causes
• Single Gene Disorders & Telomeric Deletions
• Preimplantation Genetic Testing (PGD/PGS) - An Evidence Based Update
• Male Factors
• Sperm DNA Fragmentation Index

Section 3: Endometrial Causes

• Endometrial Factors
• Endometrial Receptivity Array – ERA

Section 4: Systemic Causes

• APL Syndrome
• Autoimmune Disorders
• Hyperhomocysteinemia
• Inherited Thrombophilia
• Endocrinal Causes
• PCOS
• Poor Oocyte Quality – Ovarian Aging

Section 5: Anatomical Causes

• Anatomical Factors
• Endometriosis
• Adenomyosis
• Intrauterine Adhesions
• Cervical Cerclage – Benefits & Controversies
• Role of Endoscopy

Section 6: Infections

• Latent Genital TB & Subclinical Endometritis
• Treatment of Female Genital Tuberculosis
• Sexually Transmitted Diseases: Chlamydia, Syphilis & HIV
• Bacterial Vaginosis
• Natural Killer Cells

Section 7: Miscellaneous

• Obesity
• Late Pregnancy Loss
• Immune & Non-immune Fetal Hydrops
• Recurrent Molar Pregnancies
• Recurrent Implantation Failures & Biochemical Pregnancies
• Psychoneuroimmunology - Role of Stress

Section 8: Management Options

• Role of Progesterone
• Role of Dydrogesterone
• Role of GCSF
• Role of IVF
• Role of Lymphocyte Immunotherapy
• Oxidative Stress & Role of Antioxidants & Micronutrients
• Role of Tender Loving Care
• Management of Patients with Multiple Treatment Failures Howard Carp

Section 9: Role of Ultrasound

• Scanning the Non-pregnant Patient
• Early Pregnancy and Reassurance Scans

Section 10: Failed Pregnancy

• Role of Embryoscopy, Fetal Karyotyping & Placental Biopsy
• Surgical Versus Medical Evacuation
• Grief Counselling in Recurrent Pregnancy Loss
• Medicolegal Implications

Appendices

• Appendix 1. Role of DHEAS
• Appendix 2. Role of Uterine Stem Cells
• Appendix 3. Role of Thromboelastography
• Appendix 4. Diagnostic Tests for Autoimmunity and Alloimmunity
• Appendix 5. Algorithm on Clinical Management

Mala Arora FRCOG FICOG FICMCH
Director, Noble IVF Centre, Faridabad, Haryana; Consultant, Fortis La Femme, New Delhi, India

Neelanjana Mukhopadhaya DGO FICOG FRCOG Dip Med Edu
Consultant in Obstetrics and Gynaecology, Honorary Senior Lecturer, University College London; Luton and Dunstable University Hospital, UK