Congenital Heart Disease Molecular Genetics, Principles of Diagnosis and Treatment

This cutting-edge book encompasses the latest advances in the embryology, epidemiology, genetics, diagnosis,

imaging, and therapy of congenital heart disease. The international cast of authors are leaders in their fields and

have combined their talents to produce a unique and expert perspective on congenital heart disease. The work is

of interest to pediatricians, internal medicine specialists, medical geneticists, both pediatric and adult cardiologists, embryologists, imaging physicians, and cardiac surgeons. This book arrives at a very exciting time diseaseas new genetic, imaging, and therapeutic developments are changing the field of congenital heart disease.

It takes the reader on a journey that begins with a historical overview of congenital cardiovascular anomalies

and ends with developments in stem cell and tissue engineering. In between these chapters are destinations

that include cardiac embryogenesis, epidemiology, genetic syndromes associated with cardiovascular anomalies,

single gene disorders, cardiac imaging, surgical and interventional therapies, and ethical considerations.

Congenital Heart Disease is an invaluable reference. In short, it provides important pearls of wisdom to create a

comprehensive reference for all physicians involved with congenital heart disease.

Preface

Foreword

Overview

. Congenital Cardiovascular Anomalies: A Historical Overview

. Normal Development of the Heart

Epidemiology

. Epidemiology and Prevention of Congenital Heart Defects

. Clinical Epidemiology and Management of Congenital Heart Defects in a Developing Country

. Maternal Nongenetic Risk Factors for Congenital Heart Defects

. Adults with Congenital Heart Disease

Chromosomal Disorders

. Congenital Cardiovascular Defects in Monosomy X or Turner Syndrome

. The 22q11.2 Deletion Syndrome

. Other Genomic Disorders Causing Congenital Cardiovascular Malformations

Single Gene Disorders

. Noonan Syndrome and Other RAS/MAPK Pathway Syndromes

. The Holt-Oram Syndrome and Other Transcription Factor-Related Heart Diseases

. CHARGE Syndrome

. Alagille Syndrome

. Heterotaxy

. Molecular Genetics of Isolated Cardiovascular Malformations

. Other Single-Gene Disorders Causing Congenital Heart Disease

Arrhythmias, Cardiomyopathies, and Connective Tissue Disorders

. Genetic Arrhythmias (Channelopathies)

. Genetic Cardiomyopathies:

. Congenital Thoracic Aortic Aneurysm:

Evaluation

. The Genetic Workup for Congenital Structural Heart Disease: From Clinical to Genetic Evaluation

. Imaging of Congenital Heart Defects for the Noncardiologist:

. Prenatal Evaluation of Congenital Heart Defects and Fetal Intervention

Treatment

. Surgical Management

. Interventional Cardiology

. Ethical Considerations in Congenital Heart Disease

. The Future of Therapeutics: Stem Cells, Tissue Plasticity, and Tissue Engineering

Author Index

Subject Index