Principles of Bone Biology (4^th Ed.)

Preface from the first edition (1996): "The world of modern science is undergoing a number of spectacular events that are redefining our understanding of ourselves. As with any revolution, we should take stock of where we have been, where we are, and where we are going. Our special world of bone biology is participating in and taking advantage of the larger global revolution in modern science? we assembled experts from all over the world and asked them to focus on the current state of knowledge and the prospects for new knowledge in their area of expertise. To this end, Principles of Bone Biology was conceived." - John P. Bilezikian, Lawrence G. Raisz, Gideon A. Rodan

Praise for the previous edition: "Students, teachers, and practitioners will benefit from reading it, and investigators will use it as a reference work; it will certainly be consulted frequently." --The New England Journal of Medicine

For over two decades, "Big Gray" has been the go-to repository of knowledge in the disciplines related to bone and mineral metabolism. The fourth edition is a must-have for students new to the field; young investigators at the graduate or postgraduate level beginning their research careers; established scientists who need to keep up with the changing nature of the field, looking to enrich their own research programs, or who are changing their career direction; clinicians who want ready access to up-to-date relevant basic science.

This new edition builds on the successful formula from previous editions, taking thereader from the basic elements of fundamental research to the most sophisticated concepts in therapeutics. Principles of Bone Biology, Fourth Edition provides the most comprehensive, authoritative reference on the study of bone biology and related diseases. Bone research continues to generate enormous attention, due to the broad public health implications of osteoporosis and related bone disorders. This classic, fully updated, two volume reference is designed for anyone involved in the study of bone biology.

Volume 1 Part I: Basic principles Section A Cell biology 1. Molecular and cellular regulation of intramembranous and endochondral bone formation during embryogenesis 2. Skeletal stem cells: tissue-specific stem/progenitor cells of cartilage, bone, stroma, and marrow adipocytes 3. Bone marrow and the hematopoietic stem cell niche 4. The osteoblast lineage: its actions and communication mechanisms 5. Osteoclasts 6. The osteocyte 7. Transcriptional control of osteoblast differentiation and function 8. Wnt signaling and bone cell activity 9. Vascular and nerve interactions 10. Coupling of bone formation and resorption 11. Modeling and remodeling: the cellular machinery responsible for bone’s material and structural strength during growth, aging, and drug therapy 12. Aging and bone

Section B Biochemistry 13. Type I collagen structure, synthesis, and regulation 14. Collagen cross-linking and bone pathobiology 15. Secreted noncollagenous proteins of bone 16. Bone proteinases 17. Integrins and other cell surface attachment molecules of bone cells 18. Intercellular junctions and cellecell communication in the skeletal system

Section C Bone remodeling and mineral homeostasis 19. Histomorphometric analysis of bone remodeling 20. Phosphorus homeostasis and related disorders 21. Magnesium homeostasis 22. Metal ion toxicity in the skeleton: lead and aluminum 23. Biology of the extracellular calcium-sensing receptor

Section D Endocrine and paracrine regulation of bone 24. Parathyroid hormone molecular biology 25. Paracrine parathyroid hormonee related protein in bone: physiology and pharmacology 26. Cardiovascular actions of parathyroid hormone/parathyroid hormoneerelated protein signaling 27. Parathyroid hormone and parathyroid hormoneerelated protein actions on bone and kidney 28. Receptors for parathyroid hormone and parathyroid hormoneerelated protein 29. Structure and function of the vitamin D-binding proteins 30. Vitamin D gene regulation 31. Nonskeletal effects of vitamin D: current status and potential paths forward 32. Cellular actions of parathyroid hormone on bone 33. Calcitonin peptides 34. Regulation of bone remodeling by central and peripheral nervous signals

Section E Other systemic hormones that influence bone metabolism 35. Estrogens and progestins 36. Physiological actions of parathyroid hormone-related protein in epidermal, mammary, reproductive, and pancreatic tissues 37. The pharmacology of selective estrogen receptor modulators: past and present 38. Thyroid hormone and bone 39. Basic and clinical aspects of glucocorticoid action in bone 40. Diabetes and bone 41. Androgen receptor expression and steroid action in bone

Section F Local regulators 42. Growth hormone, insulin-like growth factors, and IGF binding proteins

Volume 2 43. The periodontium 44. Notch and its ligands 45. Fibroblast growth factor (FGF) and FGF receptor families in bone 46. Vascular endothelial growth factor and boneevascular interactions 47. Transforming growth factor-b and skeletal homeostasis 48. Bone morphogenetic proteins 49. Extraskeletal effects of RANK ligand 50. Local regulators of bone 51. Prostaglandins and bone metabolism

Part II: Molecular mechanisms of metabolic bone disease 52. The molecular actions of parathyroid hormone/parathyroid hormoneerelated protein receptor type 1 and their implications 53. Multiple endocrine neoplasia type 1 54. Parathyroid hormone-related peptide and other mediators of skeletal manifestations of malignancy 55. Localized osteolysis 56. Genetic regulation of parathyroid gland development 57. Genetic disorders caused by mutations in the parathyroid hormone/parathyroid hormonee related peptide receptor, its ligands, and downstream effector molecules 58. Molecular basis of parathyroid hormone overexpression 59. Diseases resulting from defects in the G protein Gsa 60. Renal osteodystrophy and chronic kidney diseaseemineral bone disorder 61. Osteogenesis imperfecta 62. Hereditary deficiencies in vitamin D action 63. Fibroblast growth factor 23 64. Tumor-induced osteomalacia 65. Osteopetrosis 66. Hypophosphatasia: nature’s window on alkaline phosphatase function in humans 67. Paget’s disease of bone 68. Genetic determinants of bone mass and osteoporotic fracture

Part III: Pharmacological mechanisms of therapeutics 69. Pharmacologic mechanisms of therapeutics: parathyroid hormone 70. Calcium 71. Drugs acting on the calcium receptor: calcimimetics and calcilytics 72. Clinical and translational pharmacology of bisphosphonates 73. Pharmacological mechanisms of therapeutics: receptor activator of nuclear factorekappa B ligand inhibition 74. Pharmacologic basis of sclerostin inhibition 75. Vitamin D and its analogs 76. Mechanisms of exercise effects on bone quantity and quality

Part IV: Methods in bone research 77. Application of genetically modified animals in bone research 78. Bone turnover markers 79. Microimaging 80. Macroimaging 81. Methods in lineage tracing 82. Bone histomorphometry in rodents 83. Bone strength testing in rodents 84. Regulation of energy metabolism by bone-derived hormones

Dr. Bilezikian is the recipient of the Distinguished Physician Award of the Endocrine Society, the Frederic C. Bartter Award of the American Society for Bone and Mineral Research (ASBMR) for Excellence in Clinical Research and the First Annual Global Leadership Award of the International Society of Clinical Densitometry. In 2009, he received the Gideon A. Rodan Excellence in Mentorship Award from the ASBMR. He received the Laureate Distinguished Educator Award of The Endocrine Society in 2014. In 2014, he was made honorary member of the Brazilian Society of Endocrinology and Metabolism. His publications number over 700.
Dr. Martin has served on 12 state and national committees and boards, been an international lecturer for nearly 20 years, and his work has been extensively published in a total of 420 original papers, 178 reviews, chapters and editorials, and seven books. He was appointed as Officer of the Order of Australia, elected to fellowships of the Australian Academy and the Royal Society and received 12 prestigious career awards, including the Eric Susman Prize from the Royal Australasian Co

• Provides a "one-stop" shopping paradise. Anything you want to find about bone biology is here and written by the world’s experts
• THE essential resource for anyone involved in the study of the skeleton and metabolic bone diseases
• Covers everything from the basic scientific concepts to the underlying principles of therapeutics and management
• Allows readers to easily search and locate information quickly in the online format
• Volumes include: Basic Principles; Molecular Mechanisms of Metabolic Bone Disease; Pharmacological Mechanisms of Therapeutics; Methods in Bone Research