Micro Total Analysis Systems, Softcover reprint of the original 1st ed. 1995 Proceedings of the μTAS '94 Workshop, held at MESA Research Institute, University of Twente, The Netherlands, 21-22 November 1994

The MESA Research Institute of the University of Twente was created in 1990 through the joining of the research unit Sensors and Actuators with the department of Microelectronics. The multidisciplinary institute, with participation from the faculties of Electrical Engineering, Applied Physics and Chemical Technology, was recently recognized as a Centre of Excellence by the Dutch Science Foundation. It is fully 2 equipped with modem Clean Room facilities (1000 m ) and a number of research laboratories. The objective of MESA is to perform research and development of systems in modem information technology, and on the units on which they are based: the microstructures that process and transduce signals. The institute gradually expanded during the past few years till some 125 persons in 1994. Given the wide variety of research subjects within MESA, it has been decided to start a MESA Monographs series, appearing on a more or less regular, yearly basis. In this way, after some time a good overview of research topics under investigation at MESA will be obtained. The first volume of this series coincides with the Proceedings of pTAS '94, the first Workshop on Micro Total Analysis Systems, held on November 21-22 at the University of Twente in Enschede, The Netherlands. IlTAS has recently been defined as the first strategic research orientation of MESA, aiming at synergetic collaboration between the different disciplines present in MESA.

The Challenge of Developing muTAS; P. Bergveld. muTAS: Miniaturized Total Chemical Analysis Systems; A. Manz, E.M.J. Verpoorte, D.E. Raymond, C.S. Effenhauser, N. Burggraf, H.M. Widmer. Chances of muTAS in Analytical Chemistry; W.E. van der Linden. muTAS for Biochemical Analysis; I. Karube. Detection Principles for muTAS; H.-J. Ache. Microfabricated Liquid Handling Elements; H. Sandmaier, R. Zengerle, A. Richter. Micromechanical Components for muTAS; J.H. Fluitman, A. van den Berg, T.S. Lammerink. Material Science for Future (Bio)Chemical Microsystems: the Key Role of Tailoring Interfaces; W. Göpel. Optical Microsystems for (Bio)Chemical Analysis; O.S. Wolfbeis. Integration of Analytical Systems Incorporating Chemical Reactions and Electrophoretic Separation; D.J. Harrison, K. Fluri, Zhongui Fan, K. Seiler. Flow Injection Microsystems -- There is a Past but Where is the Future? J. Ruzicka. Micromachined Flow-Through Measurement Chambers Using LAPS Chemical Sensors; L. Bousse, R. McReynolds. Development of a PCR Microreactor; M.A. Northrup, C. Gonzales, S. Lehew, R. Hills. Application of Miniature Analyzers: From Microfluidic Components to muTAS; J. Branebjerg, B. Fabius, P. Gravesen. Microanalysis Systems for Gases; I. Lundström, A. Lloyd-Spetz, H. Sundgren, F. Winquist. Bonding and Assembling Methods for Realizing a muTAS; S. Shoji, M. Esashi. Microsystems for Analysis in Flowing Solutions; B.H. van der Schoot, E.M.J. Verpoorte, S. Jeanneret, A. Manz, N.F. de Rooij. Combined Blood Gas Sensor for pO2, pCO2 and pH; Ph. Arquint, B.H. van der Schoot, N.F. de Rooij. A Fluid Handling and Injection Microsystem for a muTAS; N. Croce, M.C. Carrozza, P. Dario. Design of an AdaptiveUnsupervised Hybrid Microsystem for Artificial Olfaction; F.A.M. Davide, C. di Natale, A. d'Amico. Integration of an Amperometric Glucose Sensor in a &mgr;TAS; L. Forssén, H. Elderstig, L. Eng, M. Nordling. Electric Field Mediated Cell Manipulation, Characterisation and Cultivation in Highly Conductive Media; G. Fuhr, B. Wagner. Electrochemical Microanalytical System for Ionometric Measurements; W. Hoffmann, M. Bruns, B. Büstgens, E. Bychkov, H. Eggert, W. Keller, D. Maas, R. Rapp, R. Ruprecht, W. Schomburg, W. Süß. Modulator Potentiometric Measuring System for the Development and Comfortable Testing of Miniaturized Ion Sensors; W. Hoffmann, R. Rapp, H.J. Ache. A Novel Sampling Technique for Total Analysis Systems; W. Künnecke, U. Bilitewski. A Micromachined Glucose Oxidase Enzyme Reactor; T. Laurell, L. Rosengren, J. Drott. First Steps of &mgr;TAS in Latvia; A. Lúsis, J. Kleperis, V. Eglìtis, A. Lloyd-Spetz, I. Lundström, H. Sundgren, F. Winquist, G. Strautmanis, I. Slaidiňs, P. Misâns, P. Rozukalns, S. Sjulzics. Microreactor with Integrated Static Mixer and Analysis System; H. Mensinger, Th. Richter, V. Hessel, J. Döpper, W. Ehrefeld. Microelectrode Arrays as Transducers for Microanalysis Systems; H. Meyer, B. Naendorf, M. Wittkampf, B. Gründig, K. Cammann. A Stacked Multichannel Amperometric Detection System; M. Paeschke, U. Wollenberger, A. Uhlig, U. Schnakenberg, B. Wagner, R. Hintsche. Components for Microfluidic Handling Modules; W.K. Schomburg, B. Büstgens, J. Fahrenberg, D. Maas. Development of a Micro Flow-System with Integrated Biosensor Array; G. Urban, G. Jobst, P. Svasek, M. Varahram, I. Moser, E. Aschauer. Tempera