Cellular Transplantation From Laboratory to Clinic

There have been tremendous strides in cellular transplantation in recent years, leading to accepted practice for the treatment of certain diseases, and use for many others in trial phases. The long history of cellular transplantation, or the transfer of cells from one organism or region of the body to another, has been revolutionized by advances in stem cell research, as well as developments in gene therapy.

Cellular Transplants: From Lab to Clinic provides a thorough foundation of the basic science underpinning this exciting field, expert overviews of the state-of-the-art, and detailed description of clinical success stories to date, as well as insights into the road ahead. As highlighted by this timely and authoritative survey, scale-up technologies and whole organ transplantation are among the hurdles representing the next frontier.

The contents are organized into four main sections, with the first covering basic biology, including transplant immunology, the use of immunosuppressive drugs, stem cell biology, and the development of donor animals for transplantation. The next part looks at peripheral and reconstructive applications, followed by a section devoted to transplantation for diseases of the central nervous system. The last part presents efforts to address the key challenges ahead, such as identifying novel transplantable cells and integrating biomaterials and nanotechnology with cell matrices.

A. BASIC BIOLOGY OF CELL THERAPY 1. Immunology of Cell and Tissue Transplantation 2. Current Immunosuppressive Drugs and Clinical Use 3. Stem and Precursor Cells for Transplant Therapy 4. Creating Animals for Cell Xenotransplantation

B. CELL THERAPY FOR PERIPHERAL DISEASES AND RECONSTRUCTIVE APPLICATIONS 5. Islet Transplants for Diabetes: The Edmonton Protocol 6. Colton—To Come 7. Encapsulated Human Islet Allografts: Providing Safety with Efficacy 8. Strategies for Cell Replacement for Kidney Failure 9. Strategies for Extracorporeal Devices for Kidney Failure 10. Transplants for Hemophilia 11. Cell Therapy for Peripheral Diseases and Reconstructive Applications: Transplants for Lysosomal Storage Disease 12. Cellular Transplants for Liver Diseases 13. Stem Cell Transplantation for Autoimmune Diseases 14. Cardiac Cell Transplantation 15. Engineered Cylindrical Cartilage Transplantation as Tracheal Replacements 16. Muscle Cell Transplants

C. CELL THERAPY FOR CNS DISEASES. 17. Immunological Consideration in CNS Transplants 18. Neurotrophic Cell Transplants for Degenerative Diseases of the Eye 19. Transplants for Glioblastoma 20. NT2N Cell Transplantation and GDNF Treatment in Stroke: Linking Neurotrophic Factor Therapy and Neuroprotection 21. NGF Producing Cell Transplants for Alzheimer’s Disease 22. Transplants of CNTF-Producing Cells for the Treatment of Huntington’s Disease 23. Choroid Plexus Epithelial Cell Transplants for Repair of the Brain 24. Neural Transplantation in Huntington’s Disease 25. Neural Transplantation in Parkinson’s Disease 26. Transplants for Chronic Pain 27. Cell Grafting for Spinal Cord Injury Repair: Cell Replacement and Bridging Strategies 28. Human Embryonic Stem Cells, Dopaminergic Neurons, and Pathways for Developing a Parkinson's Disease Therapy

D. FUTURE AVENUES OF CELL THERAPY. 29. Concepts in Cell Therapy: From Cord Blood to Sertoli Cells 30. Immunologically Privileged Environments 31. Converging Cell Therapy with Biomaterials 32. Nanotechnology’s Impact on Cell Transplantation 33. Design and Implementation of a Cell Processing Facility 34. Developing Cell Therapy Products

• Provides detailed description of clinical trials in cell transplantation
• Review of current therapeutic approaches
• Coverage of the broad range of diseases addressed by cell therapeutics
• Discussion of stem cell biology and its role in transplantation