Advances in Clinical Chemistry

Volume 45 of the Advances in Clinical Chemistry series contains review articles of wide interest to clinical laboratory scientists and diagnostic adventurers. Articles in this volume cover such topics as Inhibins as Diagnostic Markers in Human Reproduction; uPA and PAI-1 in Breast Cancer: Review of Their Clinical Utility and Current Validation in the Prospective NNBC-3 Trial; Advances in Multiple Analyte Profiling; Immune Monitoring of Clinical Trials with Biotherapies; Dietary Modification of Brain Function: Effects on Neuroendocrine and Psychological Determinants of Mental Health and Stress Related Disorders; Menopause, Estrogen and Gonadotropins in Alzheimer?s Disease; Immunosuppression Routed via the Kynurenine Pathway: A Biochemical and Pathophysiologic Approach; and Pathophysiology of Tumor-associated Macrophages.

1. Inhibins as Diagnostic Markers in Human Reproduction
Anastasia Tsigkou, Stefano Luisi, Fernando M. Reis, Felice Petraglia


2. uPA and PAI-1 in Breast Cancer: Review of Their Clinical Utility and Current Validation in the Prospective NNBC-3 Trial
Annecke K, Schmitt M, Euler U, Zerm M, Paepke D, Paepke S, von Minckwitz G, Thomssen C, and Harbeck N

3. Advances in Multiple Analyte Profiling
Virginia M. Salas, Bruce S. Edwards, Larry A. Sklar

4. Immune Monitoring of Clinical Trials with Biotherapies
Theresa L. Whiteside

5. Dietary Modification of Brain Function: Effects on Neuroendocrine and Psychological Determinants of Mental Health and Stress Related Disorders
Waladkhani A.R., Hellhammer J.

6. Menopause, Estrogen and Gonadotropins in Alzheimer Disease
Raj K. Rolston, Gemma Casadesus, Kate M. Webber, Craig S. Atwood, Richard L. Bowen, George Perry, Mark A. Smith

7. Immunosuppression Routed via the Kynurenine Pathway: A Biochemical and Pathophysiologic Approach
Álvaro González, Nerea Varo, Estibaliz Alegre, Angel Díaz, and Ignacio Melero

8. Pathophysiology of Tumor-associated Macrophages
Ang Yuan, Jeremy J.-W. Chen, and Pan-Chyr Yang

Biochemists and clinical biochemists.

Dr Gregory S Makowski is a board certified clinical chemist and fellow of the National Academy of Clinical Biochemistry. Following receipt of his PhD in Biochemistry from the University of Connecticut Storrs, he pursued post-doctoral studies at the University of Connecticut School of Medicine in Farmington that culminated in his joint appointments in the School of Medicine and the Department of Laboratory Medicine at John Dempsey Hospital. He has numerous clinical and basic science publications and serves on various scientific and editorial boards. He is actively engaged in the training of Pathology residents and fellows in the Department of Pathology and Laboratory Medicine at Hartford Hospital. He currently serves as Vice President and Chief Scientific Officer for Clinical Laboratory Partners in Newington CT, USA.